Abstract: In the practical teaching of Histology and Embryology of Aquatic Animal, a comprehensive experimental project ＂Fish Blood Smears Preparation and Blood Cells Observation＂ is newly set. In this project, the undergraduates participate in the process of blood smears preparation, which stimulates the undergraduates′ interests in learning and improves their practical ability; the undergraduates understand the basic procedure of blood smear preparation, master the experimental technique, and exert their subjective initiative. The application of the comprehensive experimental project not only exhibits incomparable superiority to that of the common experiment but also lays a solid foundation for later professional class education and postgraduate education.Meanwhile, it also provides plenty of talents with high quality for the relevant aquaculture industry, especially in the field of fish diseases prevention and control.