益生菌在犬猫上的应用研究进展

doi:10.12160/j.issn.1672-5190.2022.03.008

摘要/Abstract

摘要： 益生菌是一种定植于宿主肠道,能够调节肠道微生态平衡,提高宿主机体健康水平的活菌制剂。目前益生菌已被证实能够对动物起到多种有益的作用。随着宠物医疗行业的快速发展,犬猫的健康越来越受到主人的重视,益生菌被广泛添加到宠物食品以及营养补充剂中,通过维持肠道微生态的平衡达到预防肠道疾病或提高肠道免疫力的目的。对益生菌的定义、种类和作用机制,以及益生菌在犬猫上的应用研究进展进行综述,以期为犬猫益生菌制剂的开发以及益生菌在宠物医疗行业的应用提供参考。

关键词: 益生菌, 犬, 猫, 肠道健康, 肠道微生态

Abstract: Probiotics are live bacterial agents that can colonize the gut of the host, maintain the intestinal microecological balance, and improve the host′s health. Probiotics have been shown to have a number of beneficial impacts on animals. With the increasing growth of the pet medical industry, owners are paying more and more attention to the health of their dogs and cats. By preserving the balance of intestinal microecology, probiotics are commonly added to pet food and nutritional supplements to prevent intestinal illnesses and boost intestinal immunity. This paper reviews the definition, varieties, and action mechanisms of probiotics, as well as the research progress on application of probiotics in dogs and cats, in hoping to serve as a reference for the development of probiotics in dogs and cats and their application in the pet medical industry.

Key words: probiotics, dogs, cats, intestinal health, intestinal microecology

中图分类号:

S829.25

刘凯莉, 罗建威, 岳珂, 陈盼, 何彦锋, 解静菲, 徐婷婷, 林露茜, 黄淑成. 益生菌在犬猫上的应用研究进展[J]. 畜牧与饲料科学, 2022, 43(3): 46-52.

LIU Kai-li, LUO Jian-wei, YUE Ke, CHEN Pan, HE Yan-feng, XIE Jing-fei, XU Ting-ting, LIN Lu-xi, HUANG Shu-cheng. Research Progress on Application of Probiotics in Dogs and Cats[J]. Animal Husbandry and Feed Science, 2022, 43(3): 46-52.

参考文献

[1] 姜长津,关志惠,覃兆鲜,等.肠道微生物与猪只健康的研究进展[J].畜禽业,2021,32(10):1-4.
[2] 阿热爱·巴合提,谭春明,李平兰.益生菌的分类及其多领域应用研究现状[J].生物加工过程,2022,20(1):88-94.
[3] 徐海燕,张和平.益生菌、益生元的研究进展[J].中华炎性肠病杂志,2019,3(3):213-214,216.
[4] WIEERS G,BELKHIR L,ENAUD R,et al.How probiotics affect the microbiota[J].Frontiers in Cellular and Infection Microbiology,2019,9:454.
[5] 张文杰. 探析乳酸菌及其生物工程研究新进展[J].科技风,2021(5):1-2.
[6] LILLY D M,STILLWELL R H.Probiotics:Growth-promoting factors produced by microorganisms[J].Science,1965,147(3659):747-748.
[7] FULLER R.Probiotics in man and animal[J].Journal of Applied Bacteriology,1989,66(5):365-378.
[8] 马小东,王道成.中药金汁与粪菌移植的现代研究进展[J].中国中西医结合消化杂志,2020,28(6):482-484.
[9] 罗金丽,顾成娟,赵林华.夜明砂、晚蚕砂、五灵脂调整肠道菌群经验——仝小林三味小方撷萃[J].吉林中医药,2020,40(1):8-11.
[10] 胡小松,姜丹,李婷,等.基于16S rRNA基因测序的陕西商洛区五灵脂菌群结构分析[J].药学学报,2019,54(12):2335-2339.
[11] SHOKRYAZDAN P,FASELEH J M, LIANG J B, et al.Probiotics:From isolation to application[J].Journal of American College of Nutrition,2017,36(8):666-676.
[12] 许栋,杨岸奇,谢拥军,等.常见益生菌在畜禽生产上的研究进展[J].湖南饲料,2021(5):15-18.
[13] 姜亚乐. 降解黄曲霉毒素B₁枯草芽孢杆菌的筛选及其功能研究[D].郑州:河南农业大学,2016.
[14] UPADHAYA S D,SHANMUGAM S K,KANG D K,et al.Preliminary assessment on potentials of probiotic B. subtilis RX7 and B. methylotrophicus C14 strains as an immune modulator in Salmonella-challenged weaned pigs[J].Tropical Animal Health and Production,2017,49(5):1065-1070.
[15] LIU C Q,ZHU Q,CHANG J,et al.Effects of Lactobacillus casei and Enterococcus faecalis on growth performance,immune function and gut microbiota of suckling piglets[J].Archives of Animal Nutrition,2017,71(2):120-133.
[16] BAILEY J R,VINCE V,WILLIANMS N A,et al.Streptococcus thermophilus NCIMB 41856 ameliorates signs of colitis in an animal model of inflammatory bowel disease[J].Beneficial Microbes,2017,8(4):605-614.
[17] 朱志明,朱旺明,蓝汉冰,等.酿酒酵母营养调控功能及其在水产饲料中的应用研究进展[J].动物营养学报,2014,26(12):3550-3560.
[18] 徐陶,星云,毛爱国.犬益生菌的研究与应用[J].中国动物保健,2021,23(7):111-113.
[19] 戴维,班博,方热军.微生态制剂的作用机理及其在畜牧生产方面的应用[J].湖南饲料,2020(3):30-32.
[20] 邹朋,汪棋,周元浩,等.益生菌在宠物中的应用[J].中国饲料,2021(1):10-14.
[21] 杨泽敏,李双,金正雨,等.益生菌的作用及在禽类生产上的研究应用概述[J].贵州畜牧兽医,2021,45(3):1-4.
[22] 王国强,朱群,常娟,等.益生菌对哺乳仔猪生产性能及胃肠道生理状态的影响[J].中国兽医学报,2018,38(6):1185-1191.
[23] 崔锦,刘升辉,朱宽佑,等.丁酸梭菌、凝结芽孢杆菌和酿酒酵母发酵物对断奶仔猪生长性能、血清生化指标及肠道发育的影响[J].现代牧业,2021,5(3):5-8,25.
[24] 阿热爱·巴合提,武瑞赟,肖梦圆,等.益生菌的生理功能及作用机理研究进展[J].食品与发酵工业,2020,46(22):270-275.
[25] 王斐,徐树杰,李响,等.益生菌在猪上的应用效果和作用机理研究进展[J].动物营养学报,2021,33(11):6044-6056.
[26] CAMPBELL H K,MAIERS J L,DEMALI K A.Inter-play between tight junctions and adherens junctions[J].Experimental Cell Research,2017,358(1):39-44.
[27] YI H B,WANG L,XIONG Y X,et al.Effects of Lactobacillus reuteri LR1 on the growth performance,intestinal morphology,and intestinal barrier function in weaned pigs[J].Journal of Animal Science,2018,96(6):2342-2351.
[28] WU D Y,CAO M,ZHOU J,et al.Lactobacillus casei T1 from kurut against Helicobacter pylori-induced inflammation and the gut microbial disorder[J].Journal of Functional Foods,2021,85:104611.
[29] DARGAHI N,JOHNSON J,DONKOR O,et al.Immunomodulatory effects of probiotics:Can they be used to treat allergies and autoimmune diseases?[J].Maturitas,2019,119:25-38.
[30] 赵小平,代兴勇.益生菌的作用机制及其在畜禽生产中的应用[J].中国饲料,2020(6):21-23.
[31] 柴振宇,苑丽园,张彪,等.益生元、益生菌复合微生态制剂作用机理的研究[J].粮食与食品工业,2020,27(2):34-38.
[32] 石梦玄. 动物双歧杆菌对小鼠肠道黏膜损伤的缓解作用及其机理研究[D].邯郸:河北工程大学,2016.
[33] PACE F,PACE M,OUARTARONE G.Probiotics in digestive diseases:Focus on Lactobacillus GG[J].Minerva Gastroenterologica E Dietologica,2015,61(4):273-292.
[34] 李莲红,张名凯,ABBAS W,等.唾液乳酸杆菌SNK-6对新杨黑羽蛋鸡生产性能、蛋品质、盲肠微生物和肠道黏膜免疫功能的影响[J].中国家禽,2020,42(8):40-48.
[35] 徐春晗,徐凤宇,许祺珺.犬用益生菌研究进展[J].中国兽药杂志,2018,52(8):80-85.
[36] XU H Y,ZHAO F Y,HOU Q C,et al.Metagenomic analysis revealed beneficial effects of probiotics in improving the composition and function of the gut microbiota in dogs with diarrhoea[J].Food and Function,2019,10(5):2618-2629.
[37] 刘砚涵,夏兆飞.浅谈益生菌与宠物[C]//中国畜牧兽医学会动物微生态学分会第五届第十二次全国学术研讨会论文集.青岛:中国畜牧兽医学会动物微生态学分会,2016:27-28.
[38] 包书芳,罗佩先,陈燕妮.宠物肠道健康与营养调控研究[J].兽医导刊,2021(5):91-92.
[39] 徐文娇,方钰文,丁双阳,等.益生菌治疗宠物细菌性腹泻概述[J].微生物学报,2020,60(10):2122-2135.
[40] D′ANGELO S,FRACASSI F,BRESCIANI F,et al. Effect of Saccharomyces boulardii in dog with chronic enteropathies:Double-blinded,placebo-controlled study[J].The Veterinary Record,2018,182(9):258.
[41] POTHOULAKIS C,王建林.BLD酵母抗炎性腹泻机制的研究进展[J].饲料研究,2014(7):25-29.
[42] 刘鲜姣. 益生菌制剂治疗犬肠道疾病效果观察[J].中国工作犬业,2017(12):14-17.
[43] XU H Y,HUANG W Q,HOU Q C,et al.Oral administration of compound probiotics improved canine feed intake,weight gain,immunity and intestinal microbiota[J].Frontiers in Immunology,2019,10:666.
[44] VIOLA S,MONIKA P S,SONA G,et al.Effect of Bifidobacterium animalis B/12 administration in healthy dogs[J].Anaerobe,2014,28:37-43.
[45] MENG Y Y,LI B L,JIN D,et al.Immunomodulatory activity of Lactobacillus plantarum KLDS1.0318 in cyclophosphamide-treated mice[J].Food and Nutrition Research,2018,62:1-9.
[46] 孙宁. 乳酸菌对仔犬犬瘟热和犬细小病毒抗体效价的影响试验[J].浙江畜牧兽医,2013,38(4):38-40.
[47] ALONGE S,AIUDI G G,LACALANDRA G M,et al.Pre-and probiotics to increase the immune power of colostrum in dogs[J].Frontiers in Veterinary Science,2020,7:570414.
[48] 向大育. 复合益生菌制剂对宠物犬生长性能及血清生化指标的影响[J].饲料研究,2019,42(2):45-47.
[49] 田浪,何彦侠,侯月娥,等.复合益生菌制剂对黄羽肉鸡生产性能、抗氧化指标及免疫功能的影响[J].中国兽医学报,2017,37(8):1540-1544,1582.
[50] 赵彦光,张斌,相德才,等.饲粮中添加复合益生菌对猪生长、粪便菌群及代谢产物的影响[J].中国农业大学学报,2021,26(9):124-136.
[51] 陈如愿. 复合益生菌对断奶幼犬生长和肠道菌群及抗氧化能力的影响[D].呼和浩特:内蒙古农业大学,2016.
[52] 田其真,唐晨晨,沈丹晴,等.唾液乳酸杆菌TCSL1对幼犬生长性能、血液学与血清生化指标及肠道健康的影响[J].中国畜牧兽医,2020,47(11):3757-3766.
[53] 陆江,朱道仙,卢鹏飞,等.补喂复合益生菌制剂对幼犬生长性能、肠道动力及肠道屏障功能的影响[J].动物营养学报,2019,31(9):4242-4250.
[54] PRADEEP K,KUTTAPPA M A,PRASANA K R.Probiotics and oral health:An update[J].South African Dental Journal,2014,69(1):20-24.
[55] DAVIS E M.Gene sequence analyses of the healthy oral microbiome in humans and companion animals[J].Journal of Veterinary Dentistry,2016,33(2):97-107.
[56] ALANZI A,HONKALA S,HONKALA E,et al.Effect of Lactobacillus rhamnosus and Bifidobacterium lactis on gingival health,dental plaque,and periodontopathogens in adolescents:A randomised placebo-controlled clinical trial[J].Beneficial Microbes,2018,9(4):593-602.
[57] ADLER C J,MALIK R,BROWNE G V,et al.Diet may influence the oral microbiome composition in cats[J].Microbiome,2016,4(1):23.
[58] 孙磊,李祥林,孙孟凌,等.老年犬猫口腔疾病及其治疗[J].山东畜牧兽医,2018,39(3):42-43.
[59] ZAMBORI C,CUMPANASOIU C,MOT D,et al.The antimicrobial role of probiotics in the oral cavity in humans and dogs[J].Scientific Papers Animal Science and Biotechnologies, 2014,47(1):126-130.
[60] 韩瑨,吴燕婷,万嗣宝,等.发酵乳杆菌B44益生性能的体外评价[J].上海大学学报(自然科学版),2021,27(6):1162-1170.
[61] 朱亚丽,张广智,梁琳,等.益生菌在宠物肥胖症中的潜在应用价值[J].现代畜牧兽医,2020(9):52-57.
[62] 周其琛. 预防宠物犬、猫肥胖症和糖尿病的新方法[J].今日畜牧兽医,2018,34(2):28-29.
[63] ALEXANDER C,CROSS L,DEVENDRAN S,et al.Effects of prebiotic inulin-type fructans on blood metabolite and hormone concentrations and faecal microbiota and metabolites in overweight dogs[J].British Journal of Nutrition,2018,120(6):711-720.
[64] 刘静,朱道仙,陆江.肥胖犬粪便菌群移植对犬体况指数、血脂指标及肠道菌群的影响[J].黑龙江畜牧兽医,2020(22):147-151,169-170.
[65] JOUNG H,CHU J,KIM B K,et al.Probiotics ameliorate chronic low-grade inflammation and fat accumulation with gut microbiota composition change in diet-induced obese mice models[J]. Applied Microbiology and Biotechnology,2021,105(3):1203-1213.
[66] 胡慧灵,李惠侠.益生菌在宠物中的应用研究进展[J].畜牧产业,2021(8):61-66.
[67] 杨霁菡,栗栖凤.微生态制剂在宠物领域的应用研究[J].世界最新医学信息文摘,2019,19(94):32,35.