黄曲霉毒素对肉鸡毒性作用的研究进展

doi:10.12160/j.issn.1672-5190.2022.03.009

摘要/Abstract

摘要： 黄曲霉毒素主要是由黄曲真菌和寄生曲真菌产生的一类高毒性次级真菌代谢物质,世界范围内大部分的粮食和动物饲料受到黄曲霉毒素的污染,对动物健康与畜禽养殖业可持续发展构成严重威胁。黄曲霉毒素B₁（aflatoxin B₁,AFB₁）是众多霉菌毒素中常见且毒性较强的一种,过量摄入AFB₁具有致癌、致畸、免疫抑制等毒性效应。大量研究证实AFB₁可对肉鸡的生长、免疫功能、器官发育等方面造成严重影响,威胁家禽业的健康发展。结合国内外研究报道,对黄曲霉毒素的性质、毒性进行概述,从肠道功能障碍、免疫抑制、器官损伤和遗传毒性四个方面阐述AFB₁对肉鸡毒性作用的研究进展,以期为进一步阐明黄曲霉毒素对肉鸡毒性作用的分子机制,同时为减轻黄曲霉毒素对肉鸡养殖造成的危害提供参考。

关键词: 黄曲霉毒素B₁, 毒性, 肉鸡, 免疫抑制

Abstract: Aflatoxins are mainly a class of highly toxic secondary fungal metabolites produced by Aspergillus flavus and Aspergillus parasiticus. Most grains and animal feeds around the world are polluted by aflatoxins, which poses a severe threat to animal health and the sustainable development of livestock and poultry breeding industry. Aflatoxin B₁（AFB₁） is a common and highly toxic mycotoxin. Excessive intake of AFB₁ has a series of toxic effects such as carcinogenesis, teratogenesis and immunosuppression. A large number of studies have confirmed that AFB₁ can seriously affect the growth, immune function and organ development of broiler chickens, and threaten the healthy development of poultry industry. Combined with the research reports in China and abroad, this paper summarizes the properties and toxicity of aflatoxins, and expounds the research progress on the toxic effects of AFB₁ on broiler chickens from the four aspects of intestinal dysfunction, immunosuppression, organ damage and genetic toxicity, which may provide a reference for further elucidating the molecular mechanism underlying the toxic effects of aflatoxins in broiler chickens and for mitigating their risk in broiler farming.

Key words: aflatoxin B₁, toxicity, broiler chickens, immunosuppression

中图分类号:

解静菲, 陈诺蔓, 李潞, 岳珂, 何彦锋, 刘凯莉, 徐婷婷, 张朝栋, 林露茜, 曹芹芹, 张喜文, 黄淑成. 黄曲霉毒素对肉鸡毒性作用的研究进展[J]. 畜牧与饲料科学, 2022, 43(3): 53-58.

XIE Jing-fei, CHEN Nuo-man, LI Lu, YUE Ke, HE Yan-feng, LIU Kai-li, XU Ting-ting, ZHANG Chao-dong, LIN Lu-xi, CAO Qin-qin, ZHANG Xi-wen, HUANG Shu-cheng. Research Progress on Toxic Effects of Aflatoxins in Broiler Chickens[J]. Animal Husbandry and Feed Science, 2022, 43(3): 53-58.

参考文献

[1] 李瑞银,闫金玲,张喆萍,等.饲料中黄曲霉毒素B₁的致毒机理及其生物脱毒技术研究进展[J].饲料研究,2020,43(10):109-112.
[2] 杨雪,高亚男,王加启,等.霉菌毒素对肠道紧密连接蛋白的影响及其调控机制[J].动物营养学报,2020,32(12):5566-5577.
[3] 王娟,王改琴,李钒,等.2020年底各地新玉米霉菌毒素风险分析[J].中国饲料,2021(9):93-97.
[4] 罗自生,秦雨,徐艳群,等.黄曲霉毒素的生物合成、代谢和毒性研究进展[J].食品科学,2015,36(3):250-257.
[5] 杨瑞琪. 饲料中黄曲霉毒素对家畜的危害及防治[J]. 中国畜牧兽医文摘,2018,34(3):246.
[6] 黄海涛. 黄曲霉毒素B₁对肉鸡生长性能影响及脱霉剂的使用效果评估[D].广州:华南农业大学,2018.
[7] RUSHING B R,SELIM M I.Aflatoxin B₁:A review on metabolism,toxicity,occurrence in food,occupational exposure,and detoxification methods[J].Food and Chemical Toxicology,2019,124:81-100.
[8] 江辉. 霉菌毒素对动物免疫系统的影响[J].畜牧与饲料科学,2015,36(10):119-120.
[9] 张志美,沈志强.黄曲霉毒素对家禽的影响及预防措施[J].家禽科学,2009(12):37-39.
[10] 侯然然,张敏红.霉菌毒素对畜禽的危害及其防控方法的研究进展[J].中国畜牧兽医,2007,34(1):13-16.
[11] 孙广勇,刘昀,许凤明,等.黄曲霉毒素对养殖业的危害及预防措施[J].畜牧与饲料科学,2007,28(6):74-77.
[12] 张禹,王海荣.饲料中黄曲霉毒素的危害及脱毒方法进展[J].饲料研究,2021,44(8):157-160.
[13] RAWAL S,KIM J E,Jr COULOMBE R.Aflatoxin B₁ in poultry:Toxicology,metabolism and prevention[J]. Research in Veterinary Science,2010,89(3):325-331.
[14] 张建梅,陈静,汪官保,等.饲料中几种主要霉菌毒素的危害及防治措施[J].畜牧与饲料科学,2012,33(Z1):74-78.
[15] 乔宏兴,姜亚乐,王永芬,等.黄曲霉毒素的危害及其脱毒方法研究进展[J].动物医学进展,2017,38(1):89-93.
[16] 计成. 霉菌毒素对家禽的危害及降解技术[J].中国家禽,2014,36(2):40-42.
[17] MEISSONNIER G M,MARIN D E,GALTIER P,et al.Modulation of the immune response by a group of fungal food contaminant,the aflatoxins[J].Nutrition and Immunity,2006,37(2):147-166.
[18] 刘兆仁,高树云,赵三强,等.黄曲霉毒素对畜禽养殖业的危害[J].农村养殖技术,2012(9):7-8.
[19] 周元军. 饲料中黄曲霉毒素的危害与防治研究进展[J].安徽农业科学,2006,34(5):913-914.
[20] 于新友,李天芝,沈志强.饲料中霉菌毒素对猪的危害及预防措施[J].养猪,2017(1):30-32.
[21] 王新慧,许宏扬,刘沛尧,等.黄曲霉毒素B₁对奶牛的危害及防控研究进展[J].中国奶牛,2021(9):44-47.
[22] 陈光明,刘建军,刘桂兰,等.霉菌毒素的研究进展[J].畜牧与饲料科学,2014,35(12):122-124.
[23] GOWDA N K S,LEDOUX D R,ROTTINGHAUS G E,et al. Efficacy of turmeric(Curcuma longa),containing a known level of curcumin,and a hydrated sodium calcium aluminosilicate to ameliorate the adverse effects of aflatoxin in broiler chicks[J].Poultry Science,2008,87(6):1125-1130.
[24] 王平,王涛,胡骁飞,等.黄曲霉毒素B₁和玉米赤霉烯酮在肉鸡体内残留及消解规律的研究[J].饲料工业,2021,42(13):42-45.
[25] 左瑞雨,王秋文,常娟,等.AFB₁降解剂对肉鸡生长性能、养分代谢及AFB₁在体内残留的影响[J].中国畜牧兽医,2017,44(2):432-439.
[26] 黄伟,谌先明.黄曲霉毒素的危害及预防措施[J].畜禽业,2014(10):38-41.
[27] 何健. 自然霉变玉米对肉鸭生产性能和免疫功能的影响及机制研究[D].雅安:四川农业大学,2011.
[28] 王勇. 黄曲霉毒素降解酶对饲喂含AFB₁日粮肉仔鸡生长性能及健康的影响[D].保定:河北农业大学,2010.
[29] SHAHID A.葡萄籽原花青素提取物抵御黄曲霉毒素B₁对肉仔鸡危害的作用及机制[D].武汉:华中农业大学,2019.
[30] CHEN X,NAEHRER K,APPLEGATE T J.Interactive effects of dietary protein concentration and aflatoxin B₁ on performance,nutrient digestibility,and gut health in broiler chicks[J].Poultry Science,2016,95(6):1312-1325.
[31] 钱英红,吉鹏华,贾淑萍,等.霉菌毒素与肉鸡胃肠道疾病之间的关系[J].畜牧与饲料科学,2015,36(1):125-126.
[32] 于正强,陈瑾,彭西,等.黄曲霉毒素B₁对雏鸡免疫器官影响的病理学观察[J].畜牧兽医学报,2015,46(8):1447-1454.
[33] 田莎,孙鑫东,宋泽和,等.吸附剂对饲喂含黄曲霉毒素B₁和T-2毒素饲粮肉鸡生长性能、器官指数、血清生化指标和抗氧化能力的影响[J].动物营养学报,2020,32(7):3143-3153.
[34] 赵华. 霉菌毒素对家禽的毒性效应及其防控措施[J].中国饲料,2021(13):12-17.
[35] 熊慧慧. 黄曲霉毒素B₁对肉仔鸡生长性能及肝脏谷胱甘肽硫转移酶表达的影响[D].上海:上海海洋大学,2016.
[36] 高亚男. 联合组学技术解析黄曲霉毒素M₁与赭曲霉毒素A共存损伤肠道屏障机理[D].北京:中国农业科学院,2020.
[37] 车超平. 不同硒源对黄曲霉毒素B₁致鸡原代肝细胞损伤的缓解作用及其机理研究[D].南京:南京农业大学,2014.
[38] 王兴赫. 姜黄素干预AFB₁致肉鸡亚慢性肝损伤的分子机制[D].哈尔滨:东北农业大学,2017.
[39] FAN Y,ZHAO L H,MA Q G,et al.Effects of Bacillus subtilis ANSB060 on growth performance,meat quality and aflatoxin residues in broilers fed moldy peanut meal naturally contaminated with aflatoxins[J].Food and Chemical Toxicology,2013,59:748-753.
[40] HUSSAIN Z,KHAN M Z,KHAN A,et al.Residues of aflatoxin B₁ in broiler meat:Effect of age and dietary aflatoxin B₁ levels[J].Food and Chemical Toxicology,2010,48(12):3304-3307.
[41] 杨玉澜. 山豆根多糖和硒缓减黄曲霉毒素B₁对肝脏毒性的机制研究[D].南京:南京农业大学,2015.
[42] 蒿艳蓉,苏建家.体内相关代谢酶对黄曲霉毒素B₁(AFB₁)代谢影响的研究进展[J].世界肿瘤杂志,2007,6(4):277-281,299.
[43] 王佳曼. 黄曲霉毒素B₁亚慢性暴露对雄性小鼠氧化、遗传系统的损伤及其作用机制[D].重庆:西南大学,2017.
[44] 龙喜带,唐月浩,曲德英,等.黄曲霉毒素B₁毒性及其发挥与DNA修复(修复相关酶)[J].右江民族医学院学报,2006,28(2):278-280.
[45] KVESI B,CSERHÁTI M,ERDÉLYI M,et al. Lack of dose-and time-dependent effects of aflatoxin B₁ on gene expression and enzymes associated with lipid peroxidation and the glutathione redox system in chicken[J].Toxins,2020,12(2):84.