功能性低聚糖或糖醇促进大鼠肠道内矿物质吸收的研究进展

doi:10.12160/j.issn.1672-5190.2022.03.010

摘要/Abstract

摘要： 功能性低聚糖或糖醇具有益生元性质,在食品和营养研究中受到特别的关注。作为盲肠发酵剂,功能性低聚糖或糖醇摄入后不受小肠消化酶的分解,进入盲肠被微生物发酵,产生短链脂肪酸,降低肠腔内pH值,促进肠黏膜上皮细胞的增殖,提高矿物质在大肠中的吸收率。综述了近年来功能性低聚糖或糖醇在大鼠肠道内对矿物质吸收的促进作用及其相关机理,以期为功能性低聚糖或糖醇在食品和饲料生产上的应用提供参考。

关键词: 功能性低聚糖或糖醇, 矿物质, 盲肠, 大鼠

Abstract: Prebiotic properties of functional oligosaccharides and sugar alcohols have sparked interest in food and nutrition research. As cecal starters, the functional oligosaccharides and sugar alcohols are not degraded by digestive enzymes in the small intestine, and then they enter the cecum to be fermented by microorganism to produce short-chain fatty acids, reduce the pH value in the intestinal lumen, and promote the proliferation of intestinal mucosal epithelial cells, to improve the absorption of minerals in the large intestine. This paper reviews the research progress on promoting effects and the related mechanisms of functional oligosaccharides and sugar alcohols on intestinal absorption of minerals in rats in recent years, in hoping to provide a reference for the application of functional oligosaccharides and sugar alcohols in food and feed production.

Key words: functional oligosaccharides and sugar alcohols, minerals, cecum, rats

中图分类号:

R151
S816.71

金晓, 苏日古嘎, 张园园. 功能性低聚糖或糖醇促进大鼠肠道内矿物质吸收的研究进展[J]. 畜牧与饲料科学, 2022, 43(3): 59-63.

XIAO J, MA Sorgog, ZHANG Yuan-yuan. Research Progress on the Roles of Functional Oligosaccharides and Sugar Alcohols in Promoting Intestinal Absorption of Minerals in Rats[J]. Animal Husbandry and Feed Science, 2022, 43(3): 59-63.

参考文献

[1] PEPINO M Y.Metabolic effects of non-nutritive sweeteners[J].Physiology and Behavior,2015,152:450-455.
[2] SLAVIN J.Fiber and prebiotics: Mechanisms and health benefits[J].Nutrients,2013,5:1417-1435.
[3] SUEZ J,KOREM T,ZEEVI D,et al.Artificial sweeteners induce glucose intolerance by altering the gut microbiota[J].Nature,2014,514(7521):181-186.
[4] DALY K,DARBY A C,SHIRAZI-BEECHEY S P. Low calorie sweeteners and gut microbiota[J].Physiology and Behavior,2016,164:494-500.
[5] TURNER A,VEYSEY M,KEELY S,et al.Intense sweeteners,taste receptors and the gut microbiome:A metabolic health perspective[J].International Journal of Environmental Research and Public Health,2020,17(11):4094.
[6] LOHNER S,TOEWS I,MEERPOHL J J.Health outcomes of non-nutritive sweeteners:Analysis of the research landscape[J].Nutrition Journal,2017,16(1):55.
[7] GLENDINNING J I.Do low-calorie sweeteners promote weight gain in rodents?[J].Physiology and Behavior,2016,164:509-513.
[8] HEIJNEN A M P,BRINK E J,LEMMENS A G,et al. Ileal pH and apparent absorption of magnesium in rats fed on diets containing either lactose or lactulose[J]. British Journal of Nutrition,1993,70(3):747-756.
[9] FUKAHORI M,SAKURAI H,AKATSU S,et al.Enhanced absorption of calcium after oral administration of maltitol in the rat intestine[J].Journal of Pharmacy and Pharmacology,1998,50(11):1227-1232.
[10] KISHI K,GODA T,TAKASE S.Maltitol increases transepithelial diffusional transfer of calcium in rat ileum[J].Life Science,1996,59(14):1133-1140.
[11] HARA H,ONOSHIMA S,NAKAGAWA C.Difructose anhydride Ⅲ promotes iron absorption in the large intestine[J].Nutrition,2010,26(1):120-127.
[12] KISHINO E,NORII M,FUJITA K,et al.Enhancement by lactosucrose of the calcium absorption from the intestine in growing rats[J].Bioscience Biotechnology and Biochemistry,2006,70(6):1485-1488.
[13] GUDIEL-URBANO M,GONI I.Effect of fructooligosaccharide on nutritional parameters and mineral bioavailability in rats[J].Journal of the Science of Food and Agriculture,2002,82:913-917.
[14] METZLER-ZEBELI B U,DECKARDT K,SCHOLLENBERGER M,et al. Lactic acid and thermal treatments trigger the hydrolysis of myo-inositol hexakisphosphate and modify the abundance of lower myo-inositol phosphates in barley (Hordeum vulgare L.)[J].PLoS One,2014,9(6):1-9.
[15] EL-ZOGHBI M,SITOHY M Z.Mineral absorption by albino rats as affected by some types of dietary pectins with different degrees of esterification[J].Nahrung,2001,45(2):114-117.
[16] XIAO J,BAI G,SAKAGUCHI E.Short-term supplementation with dietary fructooligosaccharide and dietary mannitol elevated the absorption of calcium and magnesium in adult rats[J].Czech Journal of Animal Science,2016,61(6):281-289.
[17] CHONAN O,WATANUKI M.The effect of 6′-galactooligosaccharides on bone mineralization of rats adapted to different levels of dietary calcium[J].International Journal for Vitamin and Nutrition Research,1996,66(3):244-249.
[18] BROMMAGE R,BINACUA C,ANTILLE S,et al.Intestinal calcium absorption in rats is stimulated by dietary lactulose and other resistant sugars[J].Journal of Nutrition,1993,123(12):2186-2194.
[19] XIAO J,SAKAGUCHI E,MIN X,et al.Dietary mannitol increased the absorption of calcium and magnesium in rats[J]. Journal of Animal Physiology and Animal Nutrition,2016,100(4):715-722.
[20] WEAVER C M,MARTIN B R,NAKATSU C H.Galactooligosaccharides improve mineral absorption and bone properties in growing rats through gut fermentation[J].Journal of Agricultural and Food Chemistry,2011,59(12):6501-6510.
[21] TAKASUGI S,ASHIDA K,MARUYAMA S,et al.A combination of a dairy product fermented by lactobacilli and galactooligosaccharides shows additive effects on mineral balances in growing rats with hypochlorhydria induced by a proton pump inhibitor[J].Biological Trace Element Research,2013,153(1/3):309-318.
[22] TAKASUGI S,ASHIDA K,MARUYAMA S,et al.A dairy product fermented by lactobacilli cancels the adverse effects of hypochlorhydria induced by a proton pump inhibitor on bone metabolism in growing rats[J].British Journal Nutrition,2011,106(10):1487-1494.
[23] LOBOA R,GAIEVSKI E H,De CARLI E,et al.Fructo-oligosaccharides and iron bioavailability inanaemic rats:The effects on iron species distribution,ferroportin-1expression,crypt bifurcation and crypt cell proliferation in the caecum[J]. British Journal of Nutrition,2014,112(8):1286-1295.
[24] WANG Y,ZENG T,WANG S E,et al.Fructo-oligosaccharides enhance the mineral absorption and counteract the adverse effects of phytic acid in mice[J].Nutrition,2010,26(3):305-311.
[25] SCHOLZ-AHRENS K E,SCHREZENMEIR J. Inulin and oligofructose and mineral metabolism:The evidence from animal trials[J].Journal of Nutrition,2007,137(Suppl 11):2513-2523.
[26] JOHNSON C D,LUCAS E A,HOOSHMAND S,et al.Addition of fructooligosaccharides and dried plum to soy-based diets reverses bone loss in the ovariectomized rat[J].Evidence-based Complementary and Alternative Medicine,2011,2011:836267.
[27] SATO H,IDE Y,NASU M,et al.The effects of oral xylitol administration on bone density in rat femur[J].Odontology,2011,99(1):28-33.
[28] HAMALAINEN M M.Retention of calcium from various xylitol calcium combinations in rats[J].Proceedings of the Society for Experimental Biology and Medicine,1994,205(3):253-256.
[29] GODA T,SURUGA K,TAKASE S,et al.Dietary maltitol increases calcium content and breaking force of femoral bone in ovariectomized rats[J].Journal of Nutrition,1995,125(11):2869-2873.
[30] MATTILA P T,SVANBERG M J,JAMASA T,et al.Improved bone biomechanical propertiesin xylitol-fed aged rats[J].Metabolism,2002,51(1):92-96.
[31] GODA T,KISHI K,EZAWA I,et al.The maltitol-induced increase in intestinal calcium transport increases the calcium content and breaking force of femoral bone in weanling rats[J].Journal of Nutrition,1998,128(11):2028-2031.
[32] KAIVOSOJA S M,MATTILA P T,KNUUTTILA M L.Dietary xylitol protects against the imbalance in bone metabolism during the early phase of collagen type Ⅱ-induced arthritis in dark agouti rats[J]. Metabolism,2008,57(8):1052-1055.
[33] XIAO J,LI X,MIN X,et al.Mannitol improves absorption and retention of calcium and magnesium in growing rats[J].Nutrition,2013,29(1):325-331.
[34] ROTHER K I,CONWAY E M,SYLVETSKY A C.How non-nutritive sweeteners influence hormones and health[J].Trends in Endocrinology and Metabolism,2018,29(7):230-236.
[35] YOUNES H,DEMIGNE C,BEHR S R,et al.A blend of dietary fibers increases urea disposal in the large intestine and lowers urinary nitrogen excretion in rats fed a low protein diet[J].The Journal of Nutritional Biochemistry,1996,7(9):474-480.
[36] MINEO H,HARA H,TOMITA F.Short-chain fatty acids enhance diffusional Ca transport in the epithelium of the rat cecum and colon[J].Life Science,2001,69(5):517-526.
[37] YOUNES H,COUDRAY C,BELLANGER J,et al.Effects of two fermentable carbohydrates (inulin and resistant starch) and their combination on calcium and magnesium balance in rats[J].British Journal Nutrition,2001,86(4):479-485.
[38] SCHOLZ-AHRENS K E,SCHREZENMEIR J. Inulin,oligofructose and mineral metabolism - Experimental data and mechanism[J].British Journal of Nutrition,2002, 87(Suppl 2):179-186.
[39] SCHOLZ-AHRENS K E,ACIL Y,SCHREZENMEIR J. Effect of oligofructose or dietary calcium on repeated calcium and phosphorus balances,bone mineralization and trabecular structure in ovariectomized rats[J].British Journal Nutrition,2002,88(4):365-377.
[40] RASCHKA L,DANIEL H.Mechanisms underlying the effects of inulin-type fructans on calcium absorption in the large intestine of rats[J].Bone,2005,37(5):728-735.
[41] KIEN C L,BLAUWIEKEL R,BUNN J Y,et al.Cecal infusion of butyrate increases intestinal cell proliferation in piglets[J].Journal of Nutition,2007,137(4):916-922.
[42] XIAO J,METZLER-ZEBELI B U,ZEBELI Q. Gut function-enhancing properties and metabolic effects of dietary indigestible sugars in rodents and rabbits[J].Nutrients,2015,7(10):8348-8365.
[43] SAMANTA A K,JAYAPAL N,SENANI S,et al.Prebiotic inulin:Useful dietary adjuncts to manipulate the livestock gut microflora[J]. Brazilian Journal of Microbiology,2013,44(1):1-14.
[44] TOPPING D L,CLIFTON P M.Short-chain fatty acids and human colonic function:Roles of resistant starch and nonstarch polysaccharides[J].Physiological Reviews,2001,81(3):1031-1064.
[45] LUTZ T,SCHARRER E.Effect of short-chain fatty acids on calcium absorption by the rat colon[J].Experimental Physiology,1991,76(4):615-618.
[46] ASVARUJANON P,ISHIZUKA S,HARA H.Promotive effects of non-digestible disaccharides on rat mineral absorption depend on the type of saccharide[J].Nutrition,2005,21(10):1025-1035.
[47] LAPARRA J M,DIEZ-MUNICIO M,HERREROB M,et al.Structural differences of prebiotic oligosaccharides influence their capability to enhance iron absorption in deficient rats[J].Food Function,2014,5(10):2430-2437.
[48] OHTA A,SAKAI K,TAKASAKI M,et al.Dietary heme iron does not prevent postgastrectomy anemia but fructooligosaccharides improve bioavailability of heme iron in rats[J].International Journal of Vitamin and Nutrition Researsch,1999,69(5):348-355.
[49] OHTA A,BABA S,TAKASAKI M,et al.Effects of fructooligosaccharides on the absorption of magnesium in the magnesium-deficient rat model[J].Journal of Nutritional Science and Vitaminology,1994,40(2):171-181.
[50] OHTA A,OHTSUKI M,BABA S,et al.Effects of fructooligosaccharides on the absorption of iron,calcium and magnesium in iron-deficient anemic rats[J].Journal of Nutritional Science and Vitaminology,1995,41(3):281-291.
[51] SHIGA K,NISHIMUKAI M,TOMITA F,et al.Ingestion of difructose anhydride Ⅲ,a non-digestible disaccharide,prevents gastrectomy-induced iron malabsorption and anemia in rats[J].Nutrition,2006,22(7/8):786-793.
[52] SUZUKI T,NISHIMUKAI M,SHINOKI A,et al.Ingestion of epilactose,a non-digestible disaccharide,improves postgastrectomy osteopenia and anemia in rats through the promotion of intestinal calcium and iron absorption[J]. Journal of Agricultural and Food Chemistry,2010,58(19):10787-10792.
[53] SANTOS E F D,TUSBOI K H,ARAUJO M R,et al. Ingestion of polydextrose increase the iron absorption in rats submitted to partial gastrectomy[J].Acta Cirurgica Brasileira,2010,25(6):518-524.
[54] SANTOS E F D,TUSBOI K H,ARAUJO M R,et al. Dietary galactooligosaccharides increase calcium absorption in normal and gastrectomized rats[J].Revista do Colégio Brasileiro de Cirurgiões,2011,38:186-190.
[55] MITAMURA R,HARA H.Prolonged feeding of difructose anhydride Ⅲ increases strength and mineral concentrations of the femur in ovariectomized rats[J]. British Journal Nutrition,2005,94(2):268-274.
[56] XIAO J,SAKAGUCHI E,SHI B L.Mannitol evaluated mineral absorption and bone retention in ovariectomized rats[J].Czech Journal of Food Sciences,2019,37(5):319-324.
[57] OHTA A,OHTUKI M,TAKIZAWA T,et al.Effects of fructooligosaccharides on the absorption of magnesium and calcium by cecectomized rats[J].Interinational Journal for Vitamin and Nutrition Research,1994,64(4):316-323.