Abstract: Medicinal Chemistry contains numerous knowledge points and involves a wide range of contents,resulting in the learning difficulty for students.Traditional teaching methods restrict students′thinking and are not favorable to cultivate their interests in learning.The problem-based teaching method is an improvement over the traditional methods of teaching.It emphasizes students′participation in class,problem discussion and positive thinking,and guides to cultivate the self-study abilities of students.The application of the problem-based method in teaching of Medicinal Chemistry can help students establish their self-study and lifelong learning abilities,which is a beneficial exploration on cultivating innovative pharmaceutical talent.