Abstract: In order to evaluate the efficacy and safety of applying fermented grape slag in broiler chicken, 40 AA broiler chicken were selected and divided into two groups （20 broiler chicken in each group）. The broiler chicken in test group were fed with the compound feed containing 10% fermented grape slag and the broiler chicken in control group were fed with the compound feed containing 5% cottonseed meal and 5% rapeseed meal. The test lasted for 42 days. The results showed that the daily weight gain in test group increased by 7.43% than that in control group （P〈0.05）, the feed-gain ratio decreased by 4.19% than that in control group （P〈0.05） and the cull-and-death rate reached 0. The skin color, muscle pH, muscle flexibility, muscle smell, wet weight of organs, identification index of cooking broth and taste evaluation appeared normal. The haemoglobin content in test group was significantly lower than that in control group （P〈0.05）, and other indices in test group had no significant difference with control group （P〉0.05）. The contents of total bilirubin and ~/-glutamyl-transferase in test group were significantly lower than that in control group （P〈0.01）, alkaline phosphatase, creatinine and uric acid in test group were significantly lower than that in control group （P〈0.05）, other indices in test group had no significant difference with that in control group （P〉0.05）. As for the muscle safety, harmful microbes and harmful parasites were not detected in each group, the amount of harmful trace elements detected was within and greatly lower than the national standard specified value. And the amount of harmful trace elements in test was lower than that in control group, which indicated that it was effective and safe to apply fermented grape slag in the feed of broiler chicken.