Abstract: In order to investigate the anti-stress effects of GABA on animals, the experimental mice were administrated with 0.25, 0.5 and 1 g/（kg·BW·d） of GABA solution by gavage for 20 days, respectively. Subsequently, the anoxia tolerance test and the low and high temperature resistant test were carried out, and the content of blood lactic acid, urea nitrogen and liver glycogen were determined. The results showed that the mice administrated with GABA survived longer than those in control group. Furthermore, the blood lactic acid content of the treated groups was lower than that of the control group, and the significant reduction was observed in high and moderate dose groups （P〈0.05 or P〈0.01 ）. It was indicated that GABA was capable to enhance the anti- stress ability of the mice.