Abstract: MOOC realizes the large-scale and globalization of teaching resources in high level university and expands the knowledge chain of traditional higher education. The MOOC has a mode of immediate online test assisted by small video to carry out relevant course teaching, and its templated courses structure is easy for engineering replication. Thus, it can be predicted that MOOC will bring a qualitative change of the overall educational level and teaching mode to the local application-oriented universities. Taken Anhui Science and Technology University as an example, we discussed the feasibility, advantages and disadvantages of MOOC teaching in local application-oriented undergraduate universities.