Abstract: In order to determine the prescription process of honeycomb polysaccharide tablets, a method of sulfuric acid - phenol was used to treat a variety of pharmaceutic adjuvants, and the CaHPO4, PPVP and PVPK30 which had no interferences on determination of honeycomb polysaccharide content were screened to serve as diluent agent, disintegrating agent and binder, respectively. Furthermore, using the doses of pharmaceutic adjuvants and the tableting pressure as indices, the prescription was screened by L9 （34） orthogonal test combined with comprehensive scoring method. The results showed that the optimized prescription process was 22% of honeycomb polysaccharide, 52% of CaHPO4, 10% of PPVP, 15% of PVPK30 （15%） - ethanol （90%）, 1% of magnesium stearate, and 4.2 N of tableting pressure. Under this condition, three batches of samples were successfully prepared, and the friability, disintegration time limit and weight variation of them were all qualified. In addition, the average content of honeycomb polysaccharide was all above 97% and the ten-minute accumulative dissolution reached up to 90%. In conclusion, the optimized process was demonstrated to be reasonable and feasible.