Abstract: This study aimed to investigate the relationship between administrative dosage and therapeutic effect, evaluate the clinical therapeutic efficacy, and select the recommended dosage of Chaigui cold oral liquid. The exogenous wind-chill model was established with chickens. A total of 6 groups received different dosages of Chaigui cold oral liquid, a model control group, and a healthy control group were included in this study. There were 30 chickens in each group. After a continuous administration for 5 days, the chickens were observed persistently for 7 days. To determine the optimal administrative dosage, the clinical efficacy of different dosages of Chaigui cold oral liquid was comprehensively evaluated via the indicators of effective rate, curative rate and weight gain rate. The results showed that after 5 days treatment, the total effective rate, curative rate and weight gain rate of the chickens received the administration of 1.0 mL/L of Chaigui cold oral liquid were 93.33%, 76.67% and 223.40%, respectively, and those of the chickens received the administration of 8.0 mL/L of the liquid were 100%, 86.67% and 319.75%, respectively. Taking the factors of effective rate, curative rate, clinical manifestations, average weight gain and treatment cost into consideration, the clinical medication method of Chaigui cold oral liquid for exogenous wind-chill in chickens is as follows: adding 1.0 mL of the liquid in every 1 L of drinking water for continuous 3 to 5 days.

Key words: Chaigui cold oral liquid, chickens, effective rate, curative rate