腺苷酸活化蛋白激酶在奶牛疾病中的作用研究进展

doi:10.12160/j.issn.1672-5190.2022.06.002

Abstract

Abstract:

The incidence of mastitis, ketosis, fatty liver and some other diseases in dairy cow farming has increased year after year as large-scale and intensive dairy cow farming improved. As an energy receptor, AMP-activated protein kinase （AMPK） reflects the energy state of cells. AMPK plays crucial roles in glucose, lipid and protein metabolism as well as in mitochondrial biogenesis and autophagy. AMPK is thought to be a potential intervention or treatment target for a variety of diseases and has been extensively studied in metabolic diseases of dairy cows. This paper reviews the research progress on regulative roles of AMPK in dairy cow mastitis, ketosis and fatty liver, in hoping to provide references for targeted treatment of these diseases.

Key words: AMP-activated protein kinase, mastitis, fatty liver, ketosis, milk fat synthesis

CLC Number:

S858.232.2

DOU Wen-li, Baohua , CAO Pei-pei, SUN Yi-shuo, LIU Ji-guo, YANG Wen-fei, MA Yun, MA Yan-fen. Research Progress on Roles of AMP-activated Protein Kinase in Dairy Cow Diseases[J]. Animal Husbandry and Feed Science, 2022, 43(6): 6-13.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: https://journal30.magtechjournal.com/xmysl/EN/10.12160/j.issn.1672-5190.2022.06.002

https://journal30.magtechjournal.com/xmysl/EN/Y2022/V43/I6/6

References 57

[1]	XIONG W, XIONG Z Y, SONG A N, et al. Relieving lipid accumulation through UCP1 suppresses the progression of acute kidney injury by promoting the AMPK/ULK1/autophagy pathway[J]. Theranostics, 2021, 11(10):4637-4654. doi: 10.7150/thno.56082 pmid: 33754018
[2]	ZHOU X J, KUANG Y C, LIANG S M, et al. Metformin inhibits cell proliferation in SKM-1 cells via AMPK-mediated cell cycle arrest[J]. Journal of Pharmacological Sciences, 2019, 141(4):146-152. doi: S1347-8613(19)35721-4 pmid: 31744691
[3]	LI Y J, CHEN Y Y. AMPK and autophagy[M]//QIN Z H. Autophagy: Biology and Diseases, Singapore: Springer Singapore, 2019:85-108.
[4]	YAO F, JI G Y, ZHANG L. AMPK: A novel target controlling inflammation[J]. Acta Physiologica Sinica, 2012, 64(3):341-345.
[5]	LI Z, MIAO Z Y, DING L L, et al. Energy metabolism disorder mediated ammonia gas-induced autophagy via AMPK/mTOR/ULK1-Beclin1 pathway in chicken livers[J]. Ecotoxicology and Environmental Safety, 2021, 217:112219. doi: 10.1016/j.ecoenv.2021.112219
[6]	RAHMAN M A, CHO Y, NAM G, et al. Antioxidant compound, oxyresveratrol, inhibits APP production through the AMPK/ULK1/mTOR-mediated autophagy pathway in mouse cortical astrocytes[J]. Antioxidants, 2021, 10(3):408. doi: 10.3390/antiox10030408
[7]	HUNG C M, LOMBARDO P S, MALIK N, et al. AMPK/ULK1-mediated phosphorylation of Parkin ACT domain mediates an early step in mitophagy[J]. Science Advances, 2021, 7(15):eabg4544. doi: 10.1126/sciadv.abg4544
[8]	HARDIE D G, SCHAFFER B E, BRUNET A. AMPK: An energy-sensing pathway with multiple inputs and outputs[J]. Trends in Cell Biology, 2016, 26(3):190-201. doi: S0962-8924(15)00215-9 pmid: 26616193
[9]	DAVIES S P, HAWLEY S A, WOODS A, et al. Purification of the AMP-activated protein kinase on ATP-gamma-sepharose and analysis of its subunit structure[J]. European Journal of Biochemistry, 1994, 223(2):351-357. doi: 10.1111/j.1432-1033.1994.tb19001.x pmid: 8055903
[10]	BIERI M, MOBBS J I, KOAY A, et al. AMP-activated protein kinase β-subunit requires internal motion for optimal carbohydrate binding[J]. Biophysical Journal, 2012, 102(2):305-314. doi: 10.1016/j.bpj.2011.12.012 pmid: 22339867
[11]	XIAO B, SANDERS M J, CARMENA D, et al. Structural basis of AMPK regulation by small molecule activators[J]. Nature Communications, 2013, 4:3017. doi: 10.1038/ncomms4017 pmid: 24352254
[12]	LIANG J Y, XU Z X, DING Z Y, et al. Myristoylation confers noncanonical AMPK functions in autophagy selectivity and mitochondrial surveillance[J]. Nature Communications, 2015, 6:7926. doi: 10.1038/ncomms8926 pmid: 26272043
[13]	WALKER J W, JIJON H B, MADSEN K L. AMP-activated protein kinase is a positive regulator of poly(ADP-ribose) polymerase[J]. Biochemical and Biophysical Research Communications, 2006, 342(1):336-341. doi: 10.1016/j.bbrc.2006.01.145 pmid: 16480959
[14]	DE SOUZA ALMEIDA MATOS A L, OAKHILL J S, MOREIRA J, et al. Allosteric regulation of AMP-activated protein kinase by adenylate nucleotides and small-molecule drugs[J]. Biochemical Society Transactions, 2019, 47(2):733-741. doi: 10.1042/BST20180625 pmid: 31000529
[15]	LIN S C, HARDIE D G. AMPK: Sensing glucose as well as cellular energy status[J]. Cell Metabolism, 2018, 27(2):299-313. doi: 10.1016/j.cmet.2017.10.009
[16]	GARCIA D, SHAW R J. AMPK: Mechanisms of cellular energy sensing and restoration of metabolic balance[J]. Molecular Cell, 2017, 66(6):789-800. doi: S1097-2765(17)30396-9 pmid: 28622524
[17]	KIM J, YANG G, HA J. Targeting of AMP-activated protein kinase: Prospects for computer-aided drug design[J]. Expert Opinion on Drug Discovery, 2017, 12(1):47-59. pmid: 27797589
[18]	WOODS A, JOHNSTONE S R, DICKERSON K, et al. LKB1 is the upstream kinase in the AMP-activated protein kinase cascade[J]. Current Biology, 2003, 13(22):2004-2008. doi: 10.1016/j.cub.2003.10.031 pmid: 14614828
[19]	WOODS A, DICKERSON K, HEATH R, et al. Ca²⁺/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells[J]. Cell Metabolism, 2005, 2(1):21-33. doi: 10.1016/j.cmet.2005.06.005 pmid: 16054096
[20]	CARLING D, SANDERS M J, WOODS A. The regulation of AMP-activated protein kinase by upstream kinases[J]. International Journal of Obesity, 2008, 32(4):S55-S59.
[21]	ANTONIA R J, BALDWIN A S. IKK promotes cytokine-induced and cancer-associated AMPK activity and attenuates phenformin-induced cell death in LKB1-deficient cells[J]. Science Signaling, 2018, 11(538):eaan5850. doi: 10.1126/scisignal.aan5850
[22]	LIU M J, ZHANG C, XU X L, et al. Ferulic acid inhibits LPS-induced apoptosis in bovine mammary epithelial cells by regulating the NF-κB and Nrf2 signalling pathways to restore mitochondrial dynamics and ROS generation[J]. Veterinary Research, 2021, 52(1):104. doi: 10.1186/s13567-021-00973-3 pmid: 34256834
[23]	TAK P P, FIRESTEIN G S. NF-kappaB: A key role in inflammatory diseases[J]. The Journal of Clinical Investigation, 2001, 107(1):7-11. doi: 10.1172/JCI11830
[24]	PARK C S, BANG B R, KWON H S, et al. Metformin reduces airway inflammation and remodeling via activation of AMP-activated protein kinase[J]. Biochemical Pharmacology, 2012, 84(12):1660-1670. doi: 10.1016/j.bcp.2012.09.025 pmid: 23041647
[25]	BAI J R, XIE N, HOU Y, et al. The enhanced mitochondrial dysfunction by cantleyoside confines inflammatory response and promotes apoptosis of human HFLS-RA cell line via AMPK/Sirt 1/NF-κB pathway activation[J]. Biomedicine and Pharmacotherapy, 2022, 149:112847. doi: 10.1016/j.biopha.2022.112847
[26]	FERNANDEZ-MARCOS P J, AUWERX J. Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis[J]. The American Journal of Clinical Nutrition, 2011, 93(4):884S-890s.
[27]	SAJADIMAJD S, KHAZAEI M. Oxidative stress and cancer: The role of Nrf2[J]. Current Cancer Drug Targets, 2018, 18(6):538-557. doi: 10.2174/1568009617666171002144228
[28]	GUO W J, LI W, SU Y C, et al. GPR109A alleviate mastitis and enhances the blood milk barrier by activating AMPK/Nrf2 and autophagy[J]. International Journal of Biological Sciences, 2021, 17(15):4271-4284. doi: 10.7150/ijbs.62380 pmid: 34803497
[29]	LIU S Q, GUO W J, JIA Y X, et al. Menthol targeting AMPK alleviates the inflammatory response of bovine mammary epithelial cells and restores the synthesis of milk fat and milk protein[J]. Frontiers in Immunology, 2021, 12:782989. doi: 10.3389/fimmu.2021.782989
[30]	LI C, DAI S H, LU J Y, et al. Methylglyoxal: A newly detected and potentially harmful metabolite in the blood of ketotic dairy cows[J]. Journal of Dairy Science, 2018, 101(9):8513-8523. doi: S0022-0302(18)30609-X pmid: 29960773
[31]	PUPPEL K, GOŁEBIEWSKI M, SOLARCZYK P, et al. The relationship between plasma β-hydroxybutyric acid and conjugated linoleic acid in milk as a biomarker for early diagnosis of ketosis in postpartum Polish Holstein-Friesian cows[J]. BMC Veterinary Research, 2019, 15(1):1-11. doi: 10.1186/s12917-018-1758-8
[32]	杨威, 夏成, 陈媛媛, 等. 围产期酮病奶牛血液生化指标特征分析[J]. 中国兽医学报, 2019, 39(4):756-761.
[33]	MCART J A A, NYDAM D V, OETZEL G R. Epidemiology of subclinical ketosis in early lactation dairy cattle[J]. Journal of Dairy Science, 2012, 95(9):5056-5066. doi: S0022-0302(12)00519-X pmid: 22916909
[34]	RABOISSON D, MOUNIÉ M, MAIGNÉ E. Diseases, reproductive performance, and changes in milk production associated with subclinical ketosis in dairy cows: A meta-analysis and review[J]. Journal of Dairy Science, 2014, 97(12):7547-7563. doi: 10.3168/jds.2014-8237 pmid: 25306269
[35]	KOPIETZ F, RUPAR K, BERGGREEN C, et al. Inhibition of AMPK activity in response to insulin in adipocytes: Involvement of AMPK pS485, PDEs, and cellular energy levels[J]. American Journal of Physiology-Endocrinology and Metabolism, 2020, 319(3):e459-e471. doi: 10.1152/ajpendo.00065.2020
[36]	EVERETT L, GALLI A, CRABB D. The role of hepatic peroxisome proliferator-activated receptors (PPARs) in health and disease[J]. Liver, 2000, 20(3):191-199. doi: 10.1034/j.1600-0676.2000.020003191.x pmid: 10902968
[37]	CAGEN L M, DENG X, WILCOX H G, et al. Insulin activates the rat sterol-regulatory-element-binding protein 1c (SREBP-1c) promoter through the combinatorial actions of SREBP, LXR, Sp-1 and NF-Y cis-acting elements[J]. The Biochemical Journal, 2005, 385(Pt 1):207-216. doi: 10.1042/BJ20040162
[38]	LI Y, DING H Y, DONG J H, et al. Glucagon attenuates lipid accumulation in cow hepatocytes through AMPK signaling pathway activation[J]. Journal of Cellular Physiology, 2019, 234(5):6054-6066. doi: 10.1002/jcp.27258 pmid: 30478902
[39]	EDGERTON D S, KRAFT G, SMITH M, et al. Insulin′s direct hepatic effect explains the inhibition of glucose production caused by insulin secretion[J]. JCI Insight, 2017, 2(6):e91863.
[40]	LI X W, LI Y, DING H Y, et al. Insulin suppresses the AMPK signaling pathway to regulate lipid metabolism in primary cultured hepatocytes of dairy cows[J]. The Journal of Dairy Research, 2018, 85(2):157-162. doi: 10.1017/S002202991800016X
[41]	JUNG T W, PARK H S, CHOI G H, et al. β-aminoisobutyric acid attenuates LPS-induced inflammation and insulin resistance in adipocytes through AMPK-mediated pathway[J]. Journal of Biomedical Science, 2018, 25(1):27. doi: 10.1186/s12929-018-0431-7 pmid: 29592806
[42]	SHEN Y Z, CHEN L M, YANG W Z, et al. Exploration of serum sensitive biomarkers of fatty liver in dairy cows[J]. Scientific Reports, 2018, 8:13574. doi: 10.1038/s41598-018-31845-0 pmid: 30206404
[43]	HARDIE D G, ROSS F A, HAWLEY S A. AMPK: A nutrient and energy sensor that maintains energy homeostasis[J]. Nature Reviews Molecular Cell Biology, 2012, 13(4):251-262. doi: 10.1038/nrm3311 pmid: 22436748
[44]	GOLDSTEIN J, DEBOSE-BOYD R, BROWN M S. Protein sensors for membrane sterols[J]. Cell, 2006, 124:35-46. doi: 10.1016/j.cell.2005.12.022 pmid: 16413480
[45]	GEETHANGILI M, LIN C W, MERSMANN H J, et al. Methyl brevifolincarboxylate attenuates free fatty acid-induced lipid metabolism and inflammation in hepatocytes through AMPK/NF-κB signaling pathway[J]. International Journal of Molecular Sciences, 2021, 22(18):10062. doi: 10.3390/ijms221810062
[46]	YANG W, WANG S, LOOR J J, et al. Role of diacylglycerol O-acyltransferase (DGAT) isoforms in bovine hepatic fatty acid metabolism[J]. Journal of Dairy Science, 2022, 105(4):3588-3600. doi: 10.3168/jds.2021-21140 pmid: 35181144
[47]	MORENO-FERNANDEZ M E, GILES D A, STANKIEWICZ T E, et al. Peroxisomal β-oxidation regulates whole body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease[J]. JCI Insight, 2018, 3(6): e93626. doi: 10.1172/jci.insight.93626
[48]	EATON S. Control of mitochondrial beta-oxidation flux[J]. Progress in Lipid Research, 2002, 41(3):197-239. pmid: 11814524
[49]	MA H J, GUO X Z, CUI S C, et al. Dephosphorylation of AMP-activated protein kinase exacerbates ischemia/reperfusion-induced acute kidney injury via mitochondrial dysfunction[J]. Kidney International, 2022, 101(2):315-330. doi: 10.1016/j.kint.2021.10.028
[50]	KONG Y Z, ZHAO C X, TAN P P, et al. FGF21 reduces lipid accumulation in bovine hepatocytes by enhancing lipid oxidation and reducing lipogenesis via AMPK signaling[J]. Animals, 2022, 12(7):939. doi: 10.3390/ani12070939
[51]	WU Z H, TIAN M, HENG J H, et al. Current evidences and future perspectives for AMPK in the regulation of milk production and mammary gland biology[J]. Frontiers in Cell and Developmental Biology, 2020, 8:530. doi: 10.3389/fcell.2020.00530 pmid: 32671074
[52]	ABU-ELHEIGA L, BRINKLEY W R, ZHONG L, et al. The subcellular localization of acetyl-CoA carboxylase 2[J]. Proceedings of the National Academy of Sciences of the United States of America, 2000, 97(4):1444-1449.
[53]	LI N, ZHAO F, WEI C J, et al. Function of SREBP1 in the milk fat synthesis of dairy cow mammary epithelial cells[J]. International Journal of Molecular Sciences, 2014, 15(9):16998-17013. doi: 10.3390/ijms150916998 pmid: 25250914
[54]	WU Z H, LI Q H, YANG S W, et al. Energy deprivation-induced AMPK activation inhibits milk synthesis by targeting PrlR and PGC-1α[J]. Cell Communication and Signaling, 2022, 20(1):25. doi: 10.1186/s12964-022-00830-6 pmid: 35248054
[55]	JIANG W Q, ZHU Z J, THOMPSON H J. Dietary energy restriction modulates the activity of AMP-activated protein kinase, Akt, and mammalian target of rapamycin in mammary carcinomas, mammary gland, and liver[J]. Cancer Research, 2008, 68(13):5492-5499. doi: 10.1158/0008-5472.CAN-07-6721 pmid: 18593953
[56]	BURGOS S A, KIM J J M, DAI M, et al. Energy depletion of bovine mammary epithelial cells activates AMPK and suppresses protein synthesis through inhibition of mTORC1 signaling[J]. Hormone and Metabolic Research, 2013, 45(3):183-189. doi: 10.1055/s-0032-1323742 pmid: 22972179
[57]	ZHANG M C, ZHAO S G, WANG S S, et al. D-glucose and amino acid deficiency inhibits casein synthesis through JAK2/STAT5 and AMPK/mTOR signaling pathways in mammary epithelial cells of dairy cows[J]. Journal of Dairy Science, 2018, 101(2):1737-1746. doi: S0022-0302(17)31141-4 pmid: 29248227

Research Progress on Roles of AMP-activated Protein Kinase in Dairy Cow Diseases

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References 57

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	AI Junjie, DAI Xiaohua, HE Wei, SONG Linqing, WANG Yanbin, WANG Limin, FENG Haoqiang. Isolation and Identification of the Main Pathogenic Bacteria Associated with Subclinical Mastitis in Dairy Cows in Dry Period and Evaluation of In Vitro Antibacterial Effects of Two Antibiotics [J]. Animal Husbandry and Feed Science, 2024, 45(2): 122-128.
[2]	BIAN Kangkun, BAO Yulong, WANG Li. Research Progress in Molecular Regulatory Mechanisms in the Development of Non-alcoholic Fatty Liver Disease and Its Transition to Liver Cancer [J]. Animal Husbandry and Feed Science, 2023, 44(4): 29-40.
[3]	MA Gui, AN Yan-hao, MA Li-hua, SHA Ping, MA Yan-fen. Application of Metabonomics in Screening Biomarkers of Fatty Liver in Dairy Cows [J]. Animal Husbandry and Feed Science, 2023, 44(1): 38-43.
[4]	Baohua , JI Si-tong, ZHANG Chun-hua, Biligebatu , MA Yan-fen. Regulatory Mechanisms of Tea Polyphenols and Their Intervention Effects on Dairy Cow Mastitis [J]. Animal Husbandry and Feed Science, 2023, 44(1): 60-63.
[5]	JIA Zi-bo, PENG Jian-kang, ZHU Yan, CHEN Hai-feng, WANG Jing. Isolation,Identification and Antimicrobial Sensitivity Test of Staphylococcus aureus from Dairy Cow Mastitis [J]. Animal Husbandry and Feed Science, 2022, 43(1): 124-128.
[6]	ZHANG Yan-fei, WANG Li-fang. Research Advances on Extraction Technology of Plant Active Ingredients and Their Therapeutic Mechanism for Bacterial Mastitis in Dairy Cows [J]. Animal Husbandry and Feed Science, 2021, 42(6): 115-123.
[7]	. Pathogenic Microorganisms Associated Contamination in Raw Milk of Dairy Cows with Mastitis and Corresponding Control Measures [J]. Animal Husbandry and Feed Science, 2020, 41(5): 52-57.
[8]	ZHANG Jin-he, KONG Wei-jie. Isolation and Identification of Pathogenic Bacteria Associated with Clinical Mastitis in Dairy Cows and Therapeutic Effectiveness Assessment of Two Commonly Used Medication Regimens [J]. Animal Husbandry and Feed Science, 2019, 40(8): 110-112.
[9]	ZHANG Jin-he, KONG Wei-jie. Prevalence of Clinical Mastitis in Some Dairy Farms in Baoding City,Hebei Province [J]. Animal Husbandry and Feed Science, 2019, 40(7): 95-97.
[10]	ZHONG Hua-chen, WANG Li-fang, FENG Xiao-hui, ZHANG San-fen, SONG Jie. Research Progress on Dairy Cow Mastitis and Its Prevention and Control Measures [J]. Animal Husbandry and Feed Science, 2019, 40(12): 102-107.
[11]	. Research Progress on the Relationship between Trace Element Selenium and Subclinical Mastitis in Dairy Cows [J]. Animal Husbandry and Feed Science, 2018, 39(4): 103-103.
[12]	. Isolation, Identification and Antimicrobial Resistance Profiles of Staphylococcus aureus from Dairy Cows with Mastitis in Selected Regions of Inner Mongolia in 2017 [J]. Animal Husbandry and Feed Science, 2017, 38(9): 7-7.
[13]	. Liver Lipid Metabolism and Its Associated Diseases of Ruminants during Pregnancy Period [J]. Animal Husbandry and Feed Science, 2017, 38(6): 44-44.
[14]	. Research Progress on Pathogenesis of Fatty Liver Syndrome in Laying Hens [J]. Animal Husbandry and Feed Science, 2017, 38(4): 104-104.
[15]	. Inducing Factors and Nutritional Regulation of Fatty Liver Syndrome in Laying Hens [J]. Animal Husbandry and Feed Science, 2017, 38(3): 105-105.