Abstract: [Objective] To investigate the adjuvant therapeutic effect of a renal prescription diet on dogs with acute kidney injury （AKI）. [Methods] Eighteen adult dogs weighing approximately 10 kg were randomly divided into three groups （6 dogs per group）: Group A, Group B, and Group C. Dogs in Groups A and B were subcutaneously injected with gentamicin to establish a dog AKI model, while Group C received no modeling treatment. When Groups A and B reached AKI Stage Ⅲ （blood creatinine concentration of 221-439 μmol/L), conventional fluid therapy was initiated. Group A was fed a prescription diet, Group B was fed a regular diet, and Group C was fed the prescription diet. Blood and urine samples of the dogs were collected on days 0, 2, 4, 6, 8, and 10 post-modeling to measure creatinine （CREA） concentration, blood urea nitrogen （BUN） concentration, blood phosphorus concentration, total protein concentration, albumin （ALB） concentration, hematocrit （HCT）, pH, bicarbonate （HCO₃^-） concentration, urine specific gravity （USG）, and urinary sediment level and other related indicators. [Results] All measured indicators in Group C remained within the normal reference range for dogs. Key renal injury indicators, including creatinine （CREA）, blood urea nitrogen （BUN）, and blood phosphorus concentrations, decreased earlier and to a greater extent in Group A compared to Group B. By day 10 of the feeding experiment, CREA and blood phosphorus concentrations in Group A returned to the normal reference range for dogs and were significantly lower （P<0.05） than those in Group B. On days 6, 8, and 10, pH and bicarbonate （HCO₃^-） concentrations in Group A returned to the normal reference range for dogs and were significantly higher （P<0.05） than those in Group B. On days 8 and 10, USG in Group A was significantly higher （P<0.05）, while the number of casts was significantly lower （P<0.05） than in Group B, indicating earlier and faster recovery of renal function in Group A. Throughout the experiment, ALB and HCT levels in all three groups remained within the normal reference range for dogs. [Conclusion] Compared to a regular diet, the renal prescription diet exhibits a superior adjuvant therapeutic effect on dogs with AKI, providing a reference for its clinical application in companion animals.

Key words: dog, prescription diet, acute kidney injury, adjuvant therapy