Wnt10b基因的生理功能及其在绒毛周期性生长中的作用研究进展

doi:10.12160/j.issn.1672-5190.2020.03.005

畜牧与饲料科学 ›› 2020, Vol. 41 ›› Issue (3): 22-27.doi: 10.12160/j.issn.1672-5190.2020.03.005

Wnt10b基因的生理功能及其在绒毛周期性生长中的作用研究进展

穆卿^{1, 2}, 王瑞雪^{1, 2}, 王荣^{1, 2}, 周健^{1, 2}, 刘俊阳^{1, 2}, 刘佳森³, 赵艳红^{1, 2}

1.内蒙古农业大学动物科学学院,内蒙古呼和浩特 010018;
2.内蒙古自治区动物遗传育种与繁殖重点实验室,内蒙古呼和浩特 010018;
3.内蒙古自治区农牧业科学院,内蒙古呼和浩特 010031

收稿日期:2020-03-22 出版日期:2020-05-30 发布日期:2020-06-17
通讯作者: 赵艳红（1967—）,女,教授,博士,博士生导师,主要从事绒山羊遗传育种研究工作。刘佳森（1978—）,男,研究员,博士,主要研究方向为动物表观遗传调控机制。赵艳红、刘佳森为共同通信作者。
作者简介:穆卿（1993—）,男,硕士,主要从事绒山羊遗传育种研究工作。
基金资助:
国家自然科学基金项目（31860628，31460588，31560624）；内蒙古自然科学基金项目（2017MS0304）；内蒙古农牧业科技创新基金项目（2017CXJJM01-3）。

Research Advances on Physiological Function of Wnt10b Gene and Its Role in Periodic Growth of Cashmere

MU Qing^{1, 2}, WANG Rui-xue^{1, 2}, WANG Rong^{1, 2}, ZHOU Jian^{1, 2}, LIU Jun-yang^{1, 2}, LIU Jia-sen³, ZHAO Yan-hong^{1, 2}

1.College of Animal Science,Inner Mongolia Agricultural University,Hohhot 010018,China;
2.Inner Mongolia Key Laboratory of Animal Genetics,Breeding and Reproduction,Hohhot 010018,China;
3.Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences,Hohhot 010031,China

Received:2020-03-22 Online:2020-05-30 Published:2020-06-17

摘要/Abstract

摘要： 绒山羊的绒毛生长具有周期性的特点,受多种因素的影响。Wnt10b基因作为Wnt家族的重要成员之一,在动物体脂肪的生成、骨骼的生成和某些疾病（如肿瘤）的产生、毛囊的生成,以及毛发基板的生长与保持活性状态等方面发挥着重要作用。对Wnt10b的来源、结构、生理功能、调控机制及其对毛囊周期性生长的影响进行综述,以期为Wnt10b促进绒毛周期性生长的作用机理研究提供参考。

关键词: 绒山羊, Wnt10b基因, 毛囊, 周期性生长

Abstract: The cashmere growth of cashmere goat has the characteristic of periodicity and is affected by many factors. Wnt10b gene, as one of the important members of Wnt family, plays an important role in the formation of fat and bone, occurrence of some diseases （such as tumor）, generation of hair follicle, and the growth and active state maintenance of hair plate in animal. In this paper, the origin, structure, physiological function, regulatory mechanism of Wnt10b and its influence on the growth cycle of hair follicle are reviewed, in hoping to provide reference for understanding the mechanism of Wnt10b in promoting the periodic growth of cashmere.

Key words: cashmere goat, Wnt10b gene, hair follicle, periodic growth

中图分类号:

Q753

穆卿, 王瑞雪, 王荣, 周健, 刘俊阳, 刘佳森, 赵艳红. Wnt10b基因的生理功能及其在绒毛周期性生长中的作用研究进展[J]. 畜牧与饲料科学, 2020, 41(3): 22-27.

MU Qing, WANG Rui-xue, WANG Rong, ZHOU Jian, LIU Jun-yang, LIU Jia-sen, ZHAO Yan-hong. Research Advances on Physiological Function of Wnt10b Gene and Its Role in Periodic Growth of Cashmere[J]. Animal Husbandry and Feed Science, 2020, 41(3): 22-27.

参考文献 38

[1]	HARDIMAN G,ALBRIGHT S,TSUNODA J,et al.The mouse Wnt-10B gene isolated from helper T cells is widely expressed and a possible oncogene in BR6 mouse mammary tumorigenesis[J].Gene,1996,172(2):199-205.
[2]	LEE F S,LANE T F,KUO A,et al.Insertional mutagenesis identifies a member of the Wnt gene family as a candidate oncogene in the mammary epithelium of int-2/Fgf-3 transgenic mice[J].Proceedings of the National Academy of Sciences of the United States of America,1995,92(6):2268-2272.
[3]	KRAUSS S,KORZH V,FJOSE A,et al.Expression of four zebrafish wnt-related genes during embryogenesis[J].Development,1992,116(1):249-259.
[4]	刘维,张文广,王志新,等.Wnt10b在绒山羊皮肤中的表达[J].黑龙江畜牧兽医,2011(1):1-3.
[5]	杨映娟,李惠侠,杨公社.猪Wnt10b基因cDNA的克隆及生物信息学分析[J].中国生物化学与分子生物学报,2008,24(7):679-683.
[6]	林森,林亚秋,朱江江,等.山羊Wnt10b基因生物学特征及组织细胞表达模式分析[J].基因组学与应用生物学,2017(10):4070-4078.
[7]	VISWESWARAN M, POHL S, ARFUSO F, et al.Multi-lineage differentiation of mesenchymal stem cells-To Wnt, or not Wnt[J].The International Journal of Biochemistry and Cell Biology,2015,68:139-147.
[8]	CHUNG S S, LEE J S, KIM M,et al.Regulation of Wnt/β-catenin signaling by CCAAT/enhancer binding protein β during adipogenesis[J].Obesity,2012,20(3):482-487.
[9]	MARTÍNEZ DEL PINO L, ARANA A, ALFONSO L,et al. Adiposity and adipogenic gene expression in four different muscles in beef cattle[J].PLoS One,2017,12(6):e0179604.
[10]	LONGO K A,WRIGHT W S,KANG S,et al.Wnt10b inhibits development of white and brown adipose tissues[J].Journal of Biological Chemistry,2004,279(34):35503-35509.
[11]	YIEW N K H,CHATTERJEE T K,TANG Y L,et al.A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity[J].Journal of Biological Chemistry,2017,292(15):6312-6324.
[12]	COLLINS F L, RIOS-ARCE N D, MCCABE L R,et al. Cytokine and hormonal regulation of bone marrow immune cell Wnt10b expression[J].PLoS One,2017,12(8):e0181979.
[13]	WU M,WANG Y,SHAO J Z,et al.Cbfβ governs osteoblast-adipocyte lineage commitment through enhancing β-catenin signaling and suppressing adipogenesis gene expression[J].Proceedings of the National Academy of Sciences of the United States of America,2017,114(38):10119-10124.
[14]	JING H,SU X,GAO B,et al.Epigenetic inhibition of Wnt pathway suppresses osteogenic differentiation of BMSCs during osteoporosis[J].Cell Death and Disease,2018,9(2):176.
[15]	FITRI A R,PAVASANT P,CHAMNI S,et al.Asiaticoside induces osteogenic differentiation of human periodontal ligament cells through the Wnt pathway[J].Journal of Periodontology,2018,89(5):596-605.
[16]	LU C,SHYU J,WU C,et al.Association of anabolic effect of calcitriol with osteoclast-derived Wnt10b secretion[J].Nutrients,2018,10(9):1164.
[17]	WEND P, WEND K, KRUM S A,et al.The role of WNT10B in physiology and disease[J].Acta physiologica,2011,204(1):34-51.
[18]	CHEN Y,ZENG C,ZHAN Y,et al.Aberrant low expression of p85α in stromal fibroblasts promotes breast cancer cell metastasis through exosome-mediated paracrine Wnt10b[J].Oncogene,2017,36(33):4692-4705.
[19]	陈红漫. Wnt10a/Wnt10b及其Wnt/β-catenin通路在子宫内膜癌中的作用研究[D].天津:天津医科大学,2014.
[20]	LU H,JU D,YANG G,et al.Targeting cancer stem cell signature gene SMOC-2 overcomes chemoresistance and inhibits cell proliferation of endometrial carcinoma[J].EBioMedicine,2019,40:276-289.
[21]	YUZUGULLU H, BENHAJ K,OZTURK N,et al.Canonical Wnt signaling is antagonized by noncanonical Wnt5a in hepatocellular carcinoma cells[J].Molecular Cancer,2009,8(1):90.
[22]	浮凤洲,范晓丽,孙莉.Wnt10b在肝细胞肝癌中的表达[J].重庆医学,2014(28):3753-3756.
[23]	王林,许晓群,王郡甫.胃癌组织Wnt10b的表达及意义[J].济宁医学院学报,2014,37(1):30-32.
[24]	刘永明. Wnt10b及β-catenin在骨肉瘤组织中的表达及其临床意义[D].长沙:中南大学,2010.
[25]	PENG L,LIU Z,XIAO J,et al.MicroRNA-148a suppresses epithelial-mesenchymal transition and invasion of pancreatic cancer cells by targeting Wnt10b and inhibiting the Wnt/-catenin signaling pathway[J].Oncology Reports,2017,38(1):301-308.
[26]	林可焴,苏颖,何火聪,等.Wnt10b、β-catenin与鼻咽癌放射敏感性的关系[J].福建医药杂志,2016(6):81-85.
[27]	ULLAH A,GUL A,UMAIR M,et al.Homozygous sequence variants in the WNT10B gene underlie split hand/foot malformation[J].Genetics and Molecular Biology,2018,41(1):1-8.
[28]	DANIELS D L,EKLOF SPINK K,WEIS W I.β-catenin: molecular plasticity and drug design[J].Trends in Biochemical Science,2001,26(11):672-678.
[29]	张志丹,胡志奇,李科成,等.Wnt10b对体外培养的人毛乳头细胞诱导毛囊生成能力的影响[J].实用医学杂志,2013,29(5):688-691.
[30]	赵帅,岳耀敬,郭婷婷,等.Wnt10b、β-catenin、FGF18基因在甘肃高山细毛羊胎儿皮肤毛囊中的表达规律研究[J].甘肃农业大学学报,2015(5):6-14.
[31]	张坤,连小华,李玉红,等.Wnt10b在小鼠毛囊周期中的表达[J].第三军医大学学报,2009,31(10):891-894.
[32]	WU P,ZHANG Y,XING Y,et al.The balance of Bmp6 and Wnt10b regulates the telogen-anagen transition of hair follicles[J].Cell Communication and Signaling ,2019,17:16.
[33]	WU Z,SUN L,LIU G,et al.Hair follicle development and related gene and protein expression of skins in Rex rabbits during the first 8 weeks of life[J].Asian Australasian Journal of Animal Sciences,2019,32(4):477-484.
[34]	HARDELAND R.Melatonin, hormone of darkness and more: occurrence, control mechanisms, actions and bioactive metabolites[J].Cellular and Molecular Life Sciences,2008,65(13):2001-2018.
[35]	常子丽. 持续埋植褪黑素对绒山羊绒毛生长特性和相关基因影响的研究[D].呼和浩特:内蒙古农业大学,2010.
[36]	王岩. 基于RNA-seq分析褪黑素对内蒙古绒山羊毛囊发育相关基因表达的影响[D].呼和浩特:内蒙古农业大学,2017.
[37]	丽春,张文广,常子丽,等.Wnt10b参与外源褪黑激素促进绒山羊绒毛生长的研究[J].中国畜牧杂志,2012,48(7):5-8.
[38]	穆卿. 褪黑激素对内蒙古绒山羊毛囊生长周期及Wnt10b、β-catenin基因表达的影响[D].呼和浩特:内蒙古农业大学,2018.

Wnt10b基因的生理功能及其在绒毛周期性生长中的作用研究进展

Research Advances on Physiological Function of Wnt10b Gene and Its Role in Periodic Growth of Cashmere

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献 38

相关文章 15

编辑推荐

Metrics

本文评价

[1]	斯钦孟和, 李胜利, 孙海洲, 张春华, 张乐, 张彦宁, 白雨. 加强“大数据+”科技服务，助推绒山羊产业高质量发展——以内蒙古鄂尔多斯市为例[J]. 畜牧与饲料科学, 2023, 44(4): 1-9.
[2]	高宇, 尹俊. 哺乳动物毛囊形态发生及相关信号通路研究进展[J]. 畜牧与饲料科学, 2023, 44(2): 66-71.
[3]	任鹏跃, 桑丹, 张春华, 阿树瓦尼, 塔娜, 陶格特其, 斯钦孟和. 内蒙古鄂尔多斯市绒山羊产业发展现状及效益分析——基于鄂托克旗入户调查数据[J]. 畜牧与饲料科学, 2023, 44(1): 7-16.
[4]	吴子贤, 李蕴华, 张斌, 张军, 赵艳红, 刘佳森. 血小板衍生因子A的生理功能研究进展[J]. 畜牧与饲料科学, 2021, 42(4): 49-53.
[5]	乌力吉, 成海荣, 哈斯牧仁, 李春生, 何托雅, 崔红霞, 何云梅, 郭清亮, 王泽平, 张军锋, 乌兰其其格, 李荣. 内蒙古阿尔巴斯白绒山羊羔羊短期育肥效果与屠宰性能分析[J]. 畜牧与饲料科学, 2021, 42(3): 21-27.
[6]	巴贵, 德吉, 阿旺措吉, 张婷. 早期断奶对藏西北绒山羊背最长肌氨基酸和脂肪酸含量的影响[J]. 畜牧与饲料科学, 2021, 42(2): 62-65.
[7]	吴海青, 马跃军, 勿都巴拉, 高娃, 李玉荣. 阿尔巴斯绒山羊产绒量性状相关基因挖掘的研究[J]. 畜牧与饲料科学, 2020, 41(1): 34-41.
[8]	丽春, 李金泉, 张文广, 王思珍, 王国富, 高树新, 付绍印. 外源褪黑激素对罕山白绒山羊绒毛生长相关基因表达差异的影响[J]. 畜牧与饲料科学, 2019, 40(9): 11-16.
[9]	布日古德,刘斌,辛雷勇,吴丽媛,乌亚罕,郭庆兰,阿嘎如,阿云嘎,郝巴雅斯胡良. 绒山羊光控增绒专用棚设计与应用[J]. 畜牧与饲料科学, 2018, 39(9): 95-102.
[10]	霍敏,栗瑞兰,林奕全,王瑞军,刘志红,李金泉,张家新. 辅酶Q10对绒山羊精液冷冻保存效果的影响[J]. 畜牧与饲料科学, 2018, 39(7): 39-39.
[11]	吴玉江,德吉,普布,平措,阿旺扎西,曲久. 实施乡村振兴战略,助推绒山羊产业发展[J]. 畜牧与饲料科学, 2018, 39(6): 73-73.
[12]	王俊,王宇,呼格吉乐图,苏雅拉图,图娜拉. 鄂托克旗阿尔巴斯白绒山羊寄生虫病调查和腹泻病血清生化指标分析[J]. 畜牧与饲料科学, 2018, 39(4): 106-106.
[13]	高丽霞,王高峰,刘志红. 蛋白质组学在皮肤毛囊发育研究中的应用[J]. 畜牧与饲料科学, 2018, 39(4): 35-35.
[14]	丽春,付绍印,王建蒙,王位. 基于RNA-Seq分析褪黑激素对绒山羊皮肤基因表达的影响[J]. 畜牧与饲料科学, 2018, 39(2): 26-26.
[15]	王泽平,殷国梅,刘和平,王生云,赵存发,王东兵,王永荣,潘永圣. “敏盖”白绒山羊高效生态养殖模式探究[J]. 畜牧与饲料科学, 2018, 39(1): 72-72.