间充质干细胞发挥抗菌作用的机制研究进展

doi:10.12160/j.issn.1672-5190.2022.02.004

畜牧与饲料科学 ›› 2022, Vol. 43 ›› Issue (2): 23-27.doi: 10.12160/j.issn.1672-5190.2022.02.004

间充质干细胞发挥抗菌作用的机制研究进展

李晓奇¹, 王凤武¹, 韩健健²

1.内蒙古自治区农牧业科学院,内蒙古呼和浩特 010031;
2.通辽市动物疫病预防控制中心,内蒙古通辽 028000

收稿日期:2021-12-09 出版日期:2022-03-30 发布日期:2022-03-30
通讯作者: 王凤武（1973—）,男,副研究员,博士,主要研究方向为干细胞在动物疫病诊断和治疗中的应用。
作者简介:李晓奇（1972—）,女,畜牧师,主要从事畜牧技术推广工作。
基金资助:
内蒙古自治区科技计划项目“特色蒙兽药新产品开发及标准化生产关键技术研究与应用”（2019GG347）; 内蒙古农牧业创新基金项目“绵羊干细胞免疫增强佐剂的研究与应用”（2019CXJJM09）; 内蒙古农牧业创新基金项目“绵羊消化系统主要病原体的有效分离培养体系的构建及防控研究”（2018CXJJM06）。

Research Progress in the Mechanisms Underlying the Antibacterial Action of Mesenchymal Stem Cells

LI Xiao-qi¹, WANG Feng-wu¹, HAN Jian-jian²

1. Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences,Hohhot 010031,China;
2. Animal Disease Prevention and Control Center of Tongliao City,Tongliao 028000,China

Received:2021-12-09 Online:2022-03-30 Published:2022-03-30

摘要/Abstract

摘要： 对抗菌药物具有强耐药性的“超级细菌”对人和家畜健康造成巨大威胁。广泛、高频使用种类有限的抗菌药物治疗人、家畜以及宠物细菌感染性疾病是产生“超级细菌”的根源。寻找现有常规抗菌药物的替代品或增强剂是当前热点研究方向之一。研究表明,间充质干细胞（mesenchymal stem cells,MSCs）具有抗菌特性。理论上,MSCs有可能成为治疗细菌感染性疾病的有效手段。对MSCs影响细菌存活的作用机制以及抗菌药物可能对MSCs功能产生的影响等方面的研究进展进行综述,以期为进一步阐明MSCs抗菌作用机制、挖掘MSCs作为治疗细菌感染性疾病新方法的潜力提供参考。

关键词: 抗菌药物, 间充质干细胞, 抗菌作用, 细胞治疗, 免疫调控

Abstract: The emergence of ′superbug′ with high antimicrobial resistance poses a serious threat to human and domestic animal health. The fundamental cause of ′superbug′ is extensive and high-frequency usage of limited categories of antimicrobial agents for the treatment of bacterial infectious diseases in humans, domestic animals, and pets. One of the hottest research areas right now is discovering alternatives or enhancers for existing conventional antibiotics. Researchers have found the antibacterial characteristics of mesenchymal stem cells （MSCs）. Theoretically, MSCs have the potential to be developed as an effective means for the treatment of bacterial infectious diseases. This paper reviews the research progress in the mechanisms underlying the effects of MSCs on bacterial survival and in the possible impacts of antibiotics on MSCs functions, in hoping to provide references for further clarifying the antibacterial action mechanisms of MSCs and exploring the potential of MSCs as a novel means for therapy of bacterial infectious diseases.

Key words: antimicrobial agent, mesenchymal stem cells, antibacterial action, cell therapy, immune regulation

中图分类号:

S852.2

李晓奇, 王凤武, 韩健健. 间充质干细胞发挥抗菌作用的机制研究进展[J]. 畜牧与饲料科学, 2022, 43(2): 23-27.

LI Xiao-qi, WANG Feng-wu, HAN Jian-jian. Research Progress in the Mechanisms Underlying the Antibacterial Action of Mesenchymal Stem Cells[J]. Animal Husbandry and Feed Science, 2022, 43(2): 23-27.

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间充质干细胞发挥抗菌作用的机制研究进展

Research Progress in the Mechanisms Underlying the Antibacterial Action of Mesenchymal Stem Cells

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