菜芙蓉黄酮对贵妃鸡免疫功能、血清抗氧化能力及抗病能力的影响

doi:10.12160/j.issn.1672-5190.2025.06.002

畜牧与饲料科学 ›› 2025, Vol. 46 ›› Issue (6): 9-15.doi: 10.12160/j.issn.1672-5190.2025.06.002

菜芙蓉黄酮对贵妃鸡免疫功能、血清抗氧化能力及抗病能力的影响

张致行¹, 奚玉莲¹, 黄杰¹, 蒋玲艳¹, 何东贤^1,2, 陈孟姣¹, 石宗承¹, 陆星彤¹, 林子睿¹, 秦裕亮¹, 莫红芳^1,2, 许忠裕¹

1.广西农业职业技术大学,广西南宁 530007;
2.广西大学,广西南宁 530004

收稿日期:2025-09-11 出版日期:2025-11-30 发布日期:2026-01-26
通讯作者: 莫红芳（1991—）,女,兽医师,硕士,主要研究方向为动物疫病防控。许忠裕（1985—）,男,副研究员,主要研究方向为农业经济。
作者简介:张致行（2004—）,男,所学专业为动物医学。
基金资助:
2023年广西高校中青年教师科研基础能力提升项目（2023KY1237）;2022年广西农业职业技术大学校级课题（YKJ2240）;2025年广西农业职业技术大学校级课题（XJG2531）;中国工程科技发展战略广西研究院咨询研究项目（桂科GXYD24310005）;科技攻关与新产品试制（来科攻220823）

Effects of Abelmoschus manihot ( L.) Medic Flavonoids on the Immune Function,Serum Antioxidant Capacity and Disease Resistance of Houdan Chickens

ZHANG Zhixing¹, XI Yulian¹, HUANG Jie¹, JIANG Lingyan¹, HE Dongxian^{1, 2}, CHEN Mengjiao¹, SHI Zongcheng¹, LU Xingtong¹, LIN Zirui¹, QIN Yuliang¹, MO Hongfang^{1, 2}, XU Zhongyu¹

1. Guangxi Vocational University of Agricultural, Nanning 530007, China;
2. Guangxi University, Nanning 530004, China

Received:2025-09-11 Online:2025-11-30 Published:2026-01-26

摘要/Abstract

摘要： [目的] 旨在探究饮水中添加不同剂量的菜芙蓉黄酮[Abelmoschus manihot（L.）Medic Flavonoids,AMF]对贵妃鸡免疫器官发育、血清免疫指标、抗氧化指标和抗病能力的影响。[方法] 将120羽8周龄贵妃鸡随机均分为5组,空白对照组（C组）提供正常饮水,抗生素对照组（A组）饮水中添加0.005%金霉素,低、中、高剂量组（L、M、H组）饮水中分别添加0.05%、0.1%和0.2% AMF,42 d饲养试验结束后测定试验鸡的免疫器官指数、血清免疫指标、抗氧化指标和抗病能力指标。[结果] 与C组相比,L、H组试验鸡胸腺指数显著升高（P<0.05）;A、L、M、H组血清IgG、IgM水平均显著升高（P<0.05）,A组血清IL-6水平显著升高（P<0.05）,H组血清IL-10水平显著升高（P<0.05）;A组血清SOD含量显著降低（P<0.05）,H 组血清SOD含量显著升高（P<0.05）,A、L、M、H组血清CAT含量均显著升高（P<0.05）,A组血清MDA 含量显著升高（P<0.05）,M、H组血清MDA含量显著降低（P<0.05）;L、M、H组血清TP、ALB、GLO水平均升高（P>0.05）。与A组相比,L、H组胸腺指数升高,脾脏指数、法氏囊指数降低,M组各项免疫器官指数均降低（P>0.05）;M、H组血清IgM水平显著降低（P<0.05）,L、M、H组血清IL-6水平显著降低（P<0.05）,H组血清IL-10水平显著升高（P<0.05）;H组血清SOD含量显著升高（P<0.05）,L、M、H组血清 MDA含量均显著降低（P<0.05）;L、M、H组血清TP、ALB、GLO水平均升高（P>0.05）。[结论] 在饮水中添加AMF可促进贵妃鸡的免疫器官发育、提高血清免疫球蛋白和抗炎因子含量,增强抗氧化和抗病能力,具有良好的替抗潜力。

关键词: 菜芙蓉黄酮, 贵妃鸡, 免疫功能, 血清抗氧化, 抗病能力

Abstract: [Objective] This study aimed to investigate the effects of adding different doses of Abelmoschus manihot （L.） Medic flavonoids （AMF） to drinking water on immune organ development, serum immune indices, antioxidant indices, and disease resistance in houdan chickens. [Methods] A total of 120 eight-week-old houdan chickens were randomly divided into five groups. The blank control group （Group C） received normal drinking water; the antibiotic control group （Group A） received water supplemented with 0.005% chlortetracycline; and the low-, medium-, and high-dose AMF groups （Groups L, M, and H) received water supplemented with 0.05%, 0.1%, and 0.2% AMF, respectively. After a 42-day feeding trial, immune organ indices, serum immune indices, antioxidant indices, and disease resistance parameters were measured. [Results] Compared with Group C, the thymus index in Groups L and H increased significantly （P<0.05）. Serum IgG and IgM levels in Groups A, L, M, and H were significantly higher （P<0.05）. Serum IL-6 level was significantly elevated in Group A （P<0.05）, while IL-10 level was significantly increased in Group H （P<0.05）. Serum SOD content was significantly decreased in Group A （P<0.05） but significantly increased in Group H （P<0.05）. Serum CAT content was significantly increased in Groups A, L, M, and H （P<0.05）. Serum MDA content was significantly increased in Group A （P<0.05） but significantly decreased in Groups M and H （P<0.05）. Serum TP, ALB, and GLO levels in Groups L, M, and H were elevated, though not significantly （P>0.05）. Compared with Group A, the thymus index in Groups L and H increased, while the spleen and bursa indices decreased. All immune organ indices in Group M decreased, though not significantly （P>0.05）. Serum IgM levels in Groups M and H were significantly lower （P<0.05）. Serum IL-6 levels in Groups L, M, and H were significantly lower （P<0.05）, while IL-10 level was significantly higher in Group H （P<0.05）. Serum SOD content in Group H was significantly increased （P<0.05）, and MDA content in Groups L, M, and H was significantly decreased （P<0.05）. Serum TP, ALB, and GLO levels in Groups L, M, and H were elevated （P>0.05）. [Conclusion] Supplementation of AMF in drinking water can promote immune organ development, increase serum immunoglobulin and anti-inflammatory cytokine levels, enhance antioxidant capacity and disease resistance in houdan chickens, suggesting its potential as an antibiotic alternative.

Key words: Abelmoschus manihot（L.）Medic Flavonoids, houdan chickens, immune function, serum antioxidant capacity, disease resistance

中图分类号:

张致行, 奚玉莲, 黄杰, 蒋玲艳, 何东贤, 陈孟姣, 石宗承, 陆星彤, 林子睿, 秦裕亮, 莫红芳, 许忠裕. 菜芙蓉黄酮对贵妃鸡免疫功能、血清抗氧化能力及抗病能力的影响[J]. 畜牧与饲料科学, 2025, 46(6): 9-15.

ZHANG Zhixing¹, XI Yulian¹, HUANG Jie¹, JIANG Lingyan¹, HE Dongxian^{1, 2}, CHEN Mengjiao¹, SHI Zongcheng¹, LU Xingtong¹, LIN Zirui¹, QIN Yuliang¹, MO Hongfang^{1, 2}, XU Zhongyu¹. Effects of Abelmoschus manihot ( L.) Medic Flavonoids on the Immune Function,Serum Antioxidant Capacity and Disease Resistance of Houdan Chickens[J]. Animal Husbandry and Feed Science, 2025, 46(6): 9-15.

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菜芙蓉黄酮对贵妃鸡免疫功能、血清抗氧化能力及抗病能力的影响

Effects of Abelmoschus manihot ( L.) Medic Flavonoids on the Immune Function,Serum Antioxidant Capacity and Disease Resistance of Houdan Chickens

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