畜牧与饲料科学 ›› 2013, Vol. 34 ›› Issue (7): 39-39.doi: 10.12160/j.issn.1672-5190.2013.07.017

• 动物营养与饲料科学 • 上一篇    下一篇

紧密连接的分子结构、生物学功能及其信号调控

马燕芬[1] 红梅[2] 格根塔娜[2] 张春华[1]   

  1. [1]内蒙古农牧业科学院动物营养与饲料研究所,内蒙古呼和浩特010031 [2]内蒙古林西县农牧业局,内蒙古林西025250
  • 出版日期:2013-07-20 发布日期:2013-07-20
  • 通讯作者: 马燕芬
  • 作者简介:马燕芬(1979-),女,副研究员,博士,主要研究方向为动物营养与饲料.
  • 基金资助:
    公益性行业(农业)科研专项(200903003);内蒙古农牧业科学院青年创新基金(2012QNJJM01).

Molecular Structure and Biological Function of Tight Junction and Its Signal Regulation

MA Yan-fen Hongmei Gegentana ZHANG Chun-hua (1.Animal Nutrition and Feed Research Institute,Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences, Hohhot 010031, China;2. Linxi Bureau of Agriculture and Animal Husbandry in Inner Mongolia, Linxi 025250, China)   

  • Online:2013-07-20 Published:2013-07-20

摘要: 上皮紧密连接是由occludin、claudins、ZOs等构成的相邻细胞间连接复合体,且紧密连接与胃肠道营养物质吸收、微生物黏附关系以及维持上皮细胞通透性和屏障作用等最为密切.主要对紧密连接的分子结构、生物学功能及其信号调控方面的内容进行了综述.

Abstract: Epithelial tight junction is an intercellular junctional complex that is composed of occludin, claudins and ZOs, etc. The tight junction is closely related with gastrointestinal nutrition absorption ,microbial adhesion, the permeability and barrier function of epithelial cell. The molecular structure, biological function and signal regulation of tight junction were reviewed.

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