Abstract: Due to the compound feed contamination by mycotoxin is always occurred and serious in China, so adding mycotoxin detoxification agent, mainly including mycotoxin absorbent and biological enzyme toxincide, is one of the most wildly used methods for the detoxifieation of mycotoxin contaminated domestic animal feed. The research progress of mycotoxin detoxification agent is reviewed inthis study, so as to provide theoretical basis for the development of high efficient and nutrition conservative mycotoxin detoxification agent with broad-spectrum.