Abstract: The objective of this study was to provide basic data for artificial rearing of Schizothorax kozlovi. The domestication, artificial propagation and artificial rearing experiments were conducted by Bijie Municipal Aquaculture Techniques Extension Station of Guizhou Province in Tianbaqiao base. The routine micro-runing water pond and bionic micro-runing water pond were used as Schizothorax kozlovi domestication pond; the duplicate injection method was employed in hormone-induced spawning of female fish in artificial propagation experiment. The results showed that the wild Schizothorax kozlovi was adaptive to the artificial formulated feed after 50 days domestication; the survival rate of domesticated individual with large body size was relatively lower; under the artificial rearing condition, the propagation time was one month later than that under the wild condition; the artificial reared female fish showed higher absolute fecundity compared to the wild fish; the average absolute fecundity of the artificial reared female fish was 14 470 eggs per fish, and the insemination rate and fry production rate was 73.25% and 61.6%, respectively; after a 100 days rearing duration, the average body length of the juvenile fish was 5.8 cm, and the average survival rate was 66.3%; after a 1.5 years cultivation duration, the average body weight of the fish reached up to 1 kg. Furthermore, the survival rate of the domesticated fish was found increased in the bionic micro-tuning water pond compared to the routine microruning water pond where the Schizothorax kozlovi grew slower.