T-2毒素和HT-2毒素检测方法的研究进展

doi:10.12160/j.issn.1672-5190.2019.08.004

Abstract

Abstract: Both of T-2 toxin and HT-2 toxin belong to trichothecene mycotoxins. T-2 toxin is the most toxic mycotoxin among class A trichothecene mycotoxins. HT-2 toxin is the most important metabolite of T-2 toxin in vivo and in vitro. Both of them are widely distributed in natural environment. The research progress on detection methods for T-2 toxin and HT-2 toxin was reviewed, and the advantages and disadvantages of commonly used detection methods for T-2 toxin and HT-2 toxin were further analyzed, in hoping to provide references for scientific selection of detection methods for T-2 toxin and HT-2 toxin.

Key words: T-2 toxin, HT-2 toxin, sample extraction, detection methods

CLC Number:

S852.44

TU Di, WU Ying-xin, XIONG Kuan-kuan, YANG Ling-chen. Research Progress on Detection Methods for T-2 Toxin and HT-2 Toxin[J]. Animal Husbandry and Feed Science, 2019, 40(8): 17-22.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: https://journal30.magtechjournal.com/xmysl/EN/10.12160/j.issn.1672-5190.2019.08.004

https://journal30.magtechjournal.com/xmysl/EN/Y2019/V40/I8/17

References

[1] PAL A,ACHARYA D,SAHA D,et al.Development of a membrane-based immunofiltration assay for the detection of T-2 toxin[J].Analytical Chemistry,2004,76(14):4237-4240.
[2] KLOTZEL M,GUTSCHE B,LAUBER U,et al.Determination of 12 type A and B trichothecenes in cereals by liquid chromatography-electrospray ionization tandem mass spectrometry[J].Journal of Agricultural and Food Chemistry,2005,53(23):8904-8913.
[3] DELMULLE B,De SAEGER S,ADAMS A,et al.Development of a liquid chromatography/tandem mass spectrometry method for the simultaneous determination of 16 mycotoxins on cellulose filters and in fungal cultures[J].Rapid Communications in Mass Spectrometry,2006,20(5):771-776.
[4] LATTANZIO V M,SOLFRIZZO M,VISCONTI A.Enzymatic hydrolysis of T-2 toxin for the quantitative determination of total T-2 and HT-2 toxins in cereals[J].Analytical and Bioanalytical Chemistry,2009,395(5):1325-1358.
[5] KADOTA T,KIMURA M,HIRANO S,et al.Development of a simultaneous liquid chromatography/tandem mass spectrometric method for the determination of type B trichothecenes, their derivatives, and precursors in wheat[J].Rapid Communications in Mass Spectrometry,2011,25(23):3481-3490.
[6] STECHER G,JARUKAMJORN K,ZABORSKI P,et al.Evaluation of extraction methods for the simultaneous analysis of simple and macrocyclic trichothecenes[J]. Talanta,2007,73(2):251-257.
[7] BERTHILLER F,SCHUHMACHER R,BUTTINGER G,et al.Rapid simultaneous determination of major type A- and B-trichothecenes as well as zearalenone in maize by high performance liquid chromatography-tandem mass spectrometry[J].Journal of Chromatography A,2005,1062(2):209-216.
[8] PASCALE M,HAIDUKOWSKI M,VISCONTI A.Determination of T-2 toxin in cereal grains by liquid chromatography with fluorescence detection after immunoaffinity column clean-up and derivatization with 1-anthroylnitrile[J].Journal of Chromatography A,2003,989(2):257-264.
[9] VISCONTI A,LATTANZIO V M T,PASCALE M,et al. Analysis of T-2 and HT-2 toxins in cereal grains by immunoaffinity clean-up and liquid chromatography with fluorescence detection[J].Journal of Chromatography A,2005,1075(1):151-158.
[10] MARAGOS C M.Measurement of T-2 and HT-2 toxins in eggs by high-performance liquid chromatography with fluorescence detection[J].Journal of Food Protection,2006,69(11): 2773-2776.
[11] TREBSTEIN A,SEEFELDER W,LAUBER U,et al.Determination of T-2 and HT-2 toxins in cereals including oats after immunoaffinity cleanup by liquid chromatography and fluorescence detection[J].Journal of Agricultural and Food Chemistry,2008,56(13):4968-4975.
[12] JIMÉNEZ M,MATEO J,MATEO R. Determination of type A trichothecenes by high-performance liquid chromatography with coumarin-3-carbonyl chloride derivatisation and fluorescence detection[J].Journal of Chromatography A,2000,870(1):473-481.
[13] DALLASTA C,GALAVERNA G,BIANCARDI A,et al.Simultaneous liquid chromatography-fluorescence analysis of type A and type B trichothecenes as fluorescent derivatives via reaction with coumarin-3-carbonyl chloride[J].Journal of Chromatography A,2004,1047(2):241-247.
[14] LIPPOLIS V,PASCALE M,MARAGOS C M,et al.Improvement of detection sensitivity of T-2 and HT-2 toxins using different fluorescent labeling reagents by high-performance liquid chromatography[J].Talanta,2008,74(5):1476-1483.
[15] European Commission. Commission Regulation (EC) No.1881/2006 of 19 December 2006, ′Setting Maximum Levels for Certain Contaminants in Foodstuffs′ [EB/OL].(2006-12-19).http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=CONSLEG:2006R1881:20100701:EN:PDF.
[16] LATTANZIO V M T,SOLFRIZZO M,VISCONTI A. Determination of trichothecenes in cereals and cereal-based products by liquid chromatography-tandem mass spectrometry[J].Food Additives and Contaminants,2008,25(3):320-330.
[17] BISELLI S,HUMMERT C.Development of a multicomponent method for Fusarium toxins using LC-MS/MS and its application during a survey for the content of T-2 toxin and deoxynivalenol in various feed and food samples[J].Food Additives and Contaminants,2005,22(8):752-760.
[18] RAZZAZI-FAZELI E,RABUS B,CECON B,et al.Simultaneous quantification of A-trichothecene mycotoxins in grains using liquid chromatography-atmospheric pressure chemical ionisation mass spectrometry[J].Journal of Chromatography A,2002,968(1):129-142.
[19] HÄUBL G,BERTHILLER F,KRSKA R,et al. Suitability of a fully 13C isotope labeled internal standard for the determination of the mycotoxin deoxynivalenol by LC-MS/MS without clean up[J].Analytical and Bioanalytical Chemistry,2006,384(3):692-696.
[20] SAGAWA N,TAKINO T,KUROGOCHI S.A simple method with liquid chromatography/tandem mass spectrometry for the determination of the six trichothecene mycotoxins in rice medium[J].Bioscience,Biotechnology,and Biochemistry,2006,70(1):230-236.
[21] MAVUNGU J D D,MONBALIU S,SCIPPO M L,et al. LC-MS/MS multi-analyte method for mycotoxin determination in food supplements[J].Food Additives and Contaminants,2009,26(6): 885-895.
[22] ROMERO-GONZÁLEZ R,FRENICH A G,VIDAL J L M,et al. Determination of ochratoxin A and T-2 toxin in alcoholic beverages by hollow fiber liquid phase microextraction and ultra high-pressure liquid chromatography coupled to tandem mass spectrometry[J].Talanta,2010,82(1):171-176.
[23] HEREBIAN D,ZÜHLKE S,LAMSHÖFT M,et al. Multi-mycotoxin analysis in complex biological matrices using LC-ESI/MS:experimental study using triple stage quadrupole and LTQ-Orbitrap[J].Journal of Separation Science,2009,32(7):939-948.
[24] PETTERSSON H,BROWN C,HAUK J,et al.Survey of T-2 and HT-2 toxins by LC-MS/MS in oats and oat products from European oat mills in 2005—2009[J].Food Additives and Contaminants: Part B,2011,4(2):110-115.
[25] CHEN D,CAO X,TAO Y,et al.Development of a sensitive and robust liquid chromatography coupled with tandem mass spectrometry and a pressurized liquid extraction for the determination of aflatoxins and ochratoxin A in animal derived foods[J].Journal of Chromatography A,2012,1253:110-119.
[26] ZOU Z,HE Z,LI H,et al.Development and application of a method for the analysis of two trichothecenes: deoxynivalenol and T-2 toxin in meat in China by HPLC-MS/MS[J].Meat Science,2012,90(3):613-617.
[27] BAERE S D,GOOSSENS J,OSSELAERE A,et al.Quantitative determination of T-2 toxin, HT-2 toxin, deoxynivalenol and deepoxy-deoxynivalenol in animal body fluids using LC-MS-MS detection[J].Journal of Chromatography B,2011,879(24):2403-2415.
[28] YANG L,ZHAO Z,WU A,et al. Determination of trichothecenes A (T-2 toxin, HT-2 toxin,diacetoxyscirpenol) in the tissues of broilers using liquid chromatography coupled to tandem mass spectrometry[J]. Journal of Chromatography B,2013,942/943:88-97.
[29] MORRIS H R,PAXTON T,DELL A,et al.High sensitivity collisionally‐activated decomposition tandem mass spectrometry on a novel quadrupole/orthogonal‐acceleration time‐of‐flight mass spectrometer[J].Rapid Communications in Mass Spectrometry,1996,10(8):889-896.
[30] CALBIANI F,CARERI M,ELVIRI L,et al.Accurate mass measurements for the confirmation of Sudan azo-dyes in hot chilli products by capillary liquid chromatography-electrospray tandem quadrupole orthogonal-acceleration time of flight mass spectrometry[J].Journal of Chromatography A,2004,1058(1):127-135.
[31] WU J,MCALLISTER H.Exact mass measurement on an electrospray ionization time‐of‐flight mass spectrometer: error distribution and selective averaging[J].Journal of Mass Spectrometry,2003,38(10):1043-1053.
[32] TOLONEN A,UUSITALO J.Fast screening method for the analysis of total flavonoid content in plants and foodstuffs by high‐performance liquid chromatography/electrospray ionization time‐of‐flight mass spectrometry with polarity switching[J].Rapid Communications in Mass Spectrometry,2004,18(24):3113-3122.
[33] CLAUWAERT K M,Van BOCXLAER J F,MAJOR H J,et al. Investigation of the quantitative properties of the quadrupole orthogonal acceleration time‐of‐flight mass spectrometer with electrospray ionisation using 3,4 methylenedioxymethamphetamine[J].Rapid Communications in Mass Spectrometry,1999,13(14):1540-1545.
[34] MOTTIER P,GREMAUD E,GUY P A,et al.Comparison of gas chromatography-mass spectrometry and liquid chromatography-tandem mass spectrometry methods to quantify α-tocopherol and α-tocopherolquinone levels in human plasma[J].Analytical Biochemistry,2002,301(1):128-135.
[35] TANAKA H,TAKINO M,SUGITA‐KONISHI Y,et al. Development of a liquid chromatography/time‐of‐flight mass spectrometric method for the simultaneous determination of trichothecenes, zearalenone and aflatoxins in foodstuffs[J]. Rapid Communications in Mass Spectrometry,2006,20(9):1422-1428.
[36] TURNER N W,SUBRAHMANYAM S,PILETSKY S A.Analytical methods for determination of mycotoxins: a review[J].Analytica Chimica Acta,2009,632(2):168-180.
[37] SCHOLLENBERGER M,MÜLLER H M,RÜFLE M,et al. Simultaneous determination of a spectrum of trichothecene toxins out of residuals of biogas production[J].Journal of Chromatography A,2008,1193(1/2):92-96.
[38] VAZQUEZ B,FENTE C,FRANCO C,et al.Simultaneous high-performance liquid chromatographic determination of ochratoxin A and citrinin in cheese by time-resolved luminescence using terbium[J].Journal of Chromatography A,1996,727(2):185-193.
[39] EKE Z,KENDE A,TORKOS K.Simultaneous detection of A and B trichothecenes by gas chromatography with flame ionization or mass selective detection[J].Microchemical Journal,2004,78(2):211-216.
[40] TANAKA T,YONEDA A,INOUE S,et al.Simultaneous determination of trichothecene mycotoxins and zearalenone in cereals by gas chromatography-mass spectrometry[J].Journal of Chromatography A,2000,882(1):23-28.
[41] JELEN H H, WASOWICZ E.Determination of trichothecenes in wheat grain without sample cleanup using comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry[J].Journal of Chromatography A,2008,1215(1/2):203-207.
[42] CHUANG J C,Van EMON J M,JONES R,et al. Development and application of immunoaffinity column chromatography for atrazine in complex sample media[J].Analytica Chimica Acta,2007,583(1):32-39.
[43] ANKLAM E,STROKA J,BOENKE A.Acceptance of analytical methods for implementation of EU legislation with a focus on mycotoxins[J].Food Control,2002,13(3):173-183.
[44] YOSHIZAWA T,KOHNO H,IKEDA K,et al.A practical method for measuring deoxynivalenol, nivalenol, and T-2+HT-2 toxin in foods by an enzyme-linked immunosorbent assay using monoclonal antibodies[J].Bioscience,Biotechnology,and Biochemistry,2004,68(10):2076-2085.
[45] WANG J P,DUAN S X,ZHANG Y,et al.Enzyme-linked immunosorbent assay for the determination of T-2 toxin in cereals and feedstuff[J].Microchimica Acta,2010,169(1/2):137-144.

Research Progress on Detection Methods for T-2 Toxin and HT-2 Toxin

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 9

Recommended Articles

Metrics

Comments

[1]	HUANG Zhi-wei, FENG Jin, LIU Li-xiao, LI Hong-bo. Investigation, Detection and Analysis of Pollution Status of Fumonisins (B₁+B₂), Ochratoxin A, T-2 Toxin and Aflatoxin B₁ in 17 Plant Feed Raw Materials [J]. Animal Husbandry and Feed Science, 2020, 41(4): 8-12.
[2]	. Research Progress on Autophagy Detection Methods [J]. Animal Husbandry and Feed Science, 2017, 38(7): 98-98.
[3]	. Research Progress on Detection Methods of Protein in Feed [J]. Animal Husbandry and Feed Science, 2017, 38(6): 38-38.
[4]	. Processing Condition of Artemisia annua L. Extracts and Its Regulative Effect on Production of Conjugated Linoleic Acid（CLA）in Milk [J]. Animal Husbandry and Feed Science, 2016, 37(2): 47-47.
[5]	. Comparison of the Detection Methods of Immune Antibody of O-type Foot-and-mouth Disease of Pigs [J]. Animal Husbandry and Feed Science, 2014, 35(4): 117-117.
[6]	. Comparison of Detection Methods of Paratuberculosis in Sheep in Inner Mongolia [J]. Animal Husbandry and Feed Science, 2014, 35(1): 24-24.
[7]	. Progress on the Detection Methods of Melamine [J]. Animal Husbandry and Feed Science, 2012, 33(3): 50-50.
[8]	. Advance in Detection Techology for Porcine Proliferative Enteritis [J]. Animal Husbandry and Feed Science, 2009, 30(4): 114-114.
[9]	. Research Advances of the Major Genes Affecting Sheep Fecundity Characters [J]. Animal Husbandry and Feed Science, 2009, 30(3): 15-15.