替代抗生素饲料添加剂研究进展

doi:10.12160/j.issn.1672-5190.2021.03.007

Abstract

Abstract: Antibiotics are used as the main feed additives in livestock and poultry. However, their extensive applications over the past decades have resulted in a series of problems which are needed urgently to be solved. For example, antimicrobial resistance of pathogenic bacteria has been enhanced, animal immunity and animal vaccine titer have been reduced, and human health has been affected through food chain. China′ s Ministry of Agriculture and Rural Affairs had issued a notice that the use of antibiotics additives should be banned in China′ s feed industry since the year of 2020, and the feed industry has officially entered an antibiotic-free era. For a long time, researchers have been actively seeking to develop various antibiotics substitutes as well as green and harmless feed additives to eliminate or mitigate the influences brought by prohibition of using antibiotics. In this paper, the antibacterial characteristics and mechanisms of the main antibiotics substitutes are reviewed, in hoping to provide references for the application of antibacterial additives in feed after the ban of antibiotics.

Key words: antibiotics substitutes, feed additives, action mechanism

CLC Number:

S816.7

YOU Da-peng, ZHANG Xu-ying, LIU Li-na, Hongmin, WU Guo-qing, GAO Feng-lin. Research Advances on Substitutes for Antibiotics Additives[J]. Animal Husbandry and Feed Science, 2021, 42(3): 39-42.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: https://journal30.magtechjournal.com/xmysl/EN/10.12160/j.issn.1672-5190.2021.03.007

https://journal30.magtechjournal.com/xmysl/EN/Y2021/V42/I3/39

References

[1] 中华人民共和国农业农村部.中华人民共和国农业农村部公告第194号[EB/OL].(2019-07-09).http://www.xmsyj.moa.gov.cn/zcjd/201907/t20190710_6320678.htm.
[2] 周传凤,薛梅,张廷荣,等.肉鸡小麦—豆粕型饲粮添加复合酶制剂对内源消化酶活性和养分利用率的影响[J].动物营养学报,2020,32(10):4881-4894.
[3] 王利,何军,余冰,等.小麦饲粮添加木聚糖酶对生长猪生产性能和肠道微生物的影响[C]//中国畜牧兽医学会动物营养学分会第十一次全国动物营养学术研讨会论文集.北京:中国农业科学技术出版社,2012:1.
[4] 辛锦兰. 木聚糖酶及其组合对肉鸡肠道消化酶及微生物区系的影响[D].广州:华南农业大学,2011.
[5] CHOCT M, KOCHER A, WATERS D L E, et al. A comparison of three xylanases on the nutritive value of two wheats for broiler chickens[J].British Journal of Nutrition, 2004,92(1):53-61.
[6] 罗定媛. 木聚糖酶对小麦型饲粮肉鸡生长性能、血液指标及肠道发育的影响[D].杨凌:西北农林科技大学,2009.
[7] 姚军虎,袁玖,杨凤霞,等.饲粮中添加酶制剂对肉鸡生产性能及肠道发育的影响[C]//中国畜牧兽医学会家畜生态学分会第七届全国代表大会暨学术研讨会论文集.杨凌:中国畜牧兽医学会家畜生态学分会,2008:9.
[8] MOLNÁR A K, PODMANICZKY B, KÜRTI P, et al. Effect of different concentrations of Bacillus subtilis on growth performance, carcase quality, gut microflora and immune response of broiler chickens[J].British Poultry Science,2011,52(6):658-665.
[9] 冯定远. 酶制剂在饲料养殖中发挥替代抗生素作用的领域及其机理[J].饲料工业,2020,41(12):1-10.
[10] GIBSON G R, PROBERT H M, LOO J V, et al.Dietary modulation of the human colonic microbiota: updating the concept of prebiotics[J].Nutrition Research Reviews, 2004, 17:259-275.
[11] 潘春梅. 微生态制剂生产及应用[M].北京:中国农业大学出版社,2014:198-210.
[12] 庄苏,丁立人,田桂华.抗生素替代品在饲料中的应用[J].饲料研究,2019,42(3):95-99.
[13] 蔡东东. 微生态制剂在畜禽养殖业中的应用[J].安徽农学通报,2016,22(18):97-98.
[14] GEIGEROVÁ M, BUNEŠOVÁ V, VLKOVÁ E, et al. Selection of prebiotic oligosaccharides suitable for symbiotic use in calves[J].Animal Feed Science and Technology,2017,229:73-78.
[15] 孙晓先,朱振鹏,王倩倩,等.饲用益生素在动物营养中的应用[J].饲料博览,2014(1):29-32.
[16] 肖芹,沈一茹,张珊,等.复合酸化剂对肉鸡消化道pH和消化酶活性的影响[J].动物营养学报,2015,27(8):2527-2533.
[17] BRUL S, COOTE P.Preservative agents in foods. Mode of action and microbial resistance mechanisms[J].International Journal of Food Microbiology, 1999, 50(1/2):1-17.
[18] MANI-LÓPEZ E, GARCÍA H S, LÓPEZ-MALO A. Organic acids as antimicrobial to control Salmonella in meat and poultry products[J].Food Research International,2012,45(2):713-721.
[19] PAUL S K, SAMANTA G, HALDER G, et al.Effect of a combination of organic acid salts as antibiotic replacer on the performance and gut health of broiler chickens[J].Livestock Research for Rural Development,2007,19(11):171-182.
[20] 李洁云,彭翔,张俊平,等.益生菌、酸化剂、精油、酶制剂的组合和抗生素对断奶仔猪生长性能和腹泻率影响的比较试验[J].中国饲料,2015(15):12-14,18.
[21] 刘红艳,张齐,梁志勇.不同抗生素替代品在优质肉鸡后期饲料中的应用[J].畜牧与兽医,2012,44(10):49-51.
[22] KHODAMBASHI E N, ZAFARI N S,RUIZ-FERIA C A. Growth performance, digestibility, immune response and intestinal morphology of male broilers fed phosphorus deficient diets supplemented with microbial phytase and organic acids[J].Livestock Science, 2013, 157(2/3): 506-513.
[23] ZULKIFLIB I,HASHEMIA S R,DAVOODIC H.Growth performance, intestinal microflora, plasma fatty acid profile in broiler chickens fed herbal plant (Euphorbia hirta) and mix of acidifiers[J].Animal Feed Science and Technology,2012,178(3/4):167-174.
[24] 尚田田,徐彦召,杭柏林,等.抗菌肽的抗菌机理及构效关系研究进展[J].黑龙江畜牧兽医,2013(9):26-28.
[25] HANCOCK R E W, PATRZYKAT A. Clinical development of cationic antimicrobial peptides: from natural to novel antibiotics[J].Current Drug Targets Infectious Disorders,2002,2(1):79-83.
[26] ZONG X, SONG D, WANG T,et al.LFP-20, a porcine lactoferrin peptide, ameliorates LPS-induced inflammation via the MyD88/NF-κB and MyD88/MAPK signaling pathways[J].Developmental and Comparative Immunology,2015,52( 2) : 123-131.
[27] LEE H,HWANG J S,LEE J,et al.Scolopendin 2, a cationic antimicrobial peptide from centipede, and its membrane-active mechanism[J].Biochimica et Biophysica Acta,2015,1848(2):634-642.
[28] 李云香,姚倩,任玫,等.抗菌肽作用机制研究进展[J].动物医学进展,2019,40(9):98-103.
[29] 卢军霞,张宁,王娟,等.抗菌肽的作用机制及在畜禽生产中的应用[J].中国饲料,2020(4):20-22.
[30] 王晓杰,黄立新,张彩虹,等.植物提取物饲料添加剂的研究进展[J].生物质化学工程,2018(3):50-58.
[31] 刘华,刘秀斌,吴俊,等.饲用植物及其提取物在饲料替抗中的应用[J].饲料工业,2020(12):20-24.
[32] ULTEE A,BENNIK M H J,MOEZELAAR R.The phenolic hydroxyl group of carvacrol is essential for action against the food-borne pathogen Bacillus cereus[J].Applied and Environmental Microbiology,2002,68(4):1561-1568.
[33] LAMBERT R J W,SKANDAMIS P N,COOTE P J,et al.A study of the minimum inhibitory concentration and mode of action of oregano essential oil,thymol and carvacrol[J].Journal of Applied Microbiology,2001,91(3):453-462.
[34] 李春红,冯雪建,陈洁,等.大蒜素对动物免疫调节作用的研究进展[J].安徽农业科学,2008(9):3687,3689.
[35] 詹勇,沈水昌,徐仲钧,等.糖萜素饲料添加剂研究与应用[J].广东饲料,2003(2):33-35.
[36] 戚妍,郑英帅,李佳暖,等.可以替代抗生素的饲料添加剂——植物提取物[J].中国饲料添加剂,2015(5):5-7.
[37] 中华人民共和国国务院办公厅.国务院办公厅关于促进畜牧业高质量发展的意见[EB/OL].(2020-09-27)http://www.gov.cn/zhengce/content/2020-09/27/content_5547612.htm.

Research Advances on Substitutes for Antibiotics Additives

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	ZHANG Jiansheng, ZHU Yuanfang, HAI Long, NAN Jingdong, CHEN Guowang, HAO Caihong, JIA Bin, ZHANG Bei, WANG Likun, ZHANG Guohua, SHEN Sisi. Research Progress on the Action Mechanisms of Probiotics and Their Application in Swine Production [J]. Animal Husbandry and Feed Science, 2024, 45(2): 29-34.
[2]	LIANG Fang-yin, YIN Xiang-ji. Research Progress on Application of Pyriproxyfen in Prevention and Control of Pet Ectoparasites [J]. Animal Husbandry and Feed Science, 2022, 43(1): 109-114.
[3]	ZHANG Yan-fei, WANG Li-fang. Research Advances on Extraction Technology of Plant Active Ingredients and Their Therapeutic Mechanism for Bacterial Mastitis in Dairy Cows [J]. Animal Husbandry and Feed Science, 2021, 42(6): 115-123.
[4]	ZHANG Chao-dong, CAO Qin-qin, XU Ting-ting, LIN Lu-xi, YUE Ke, ZHENG Jing-jing, HUANG Shu-cheng. Effects of Total Flavonoids from Rhizoma Drynariae on Bone Metabolism and Action Mechanisms [J]. Animal Husbandry and Feed Science, 2021, 42(4): 118-123.
[5]	XU Miao, LIU Ming-yu, HUANG Zhu, JIANG Dan, XIE Gui-xiang, LIU Zhong-gang, WANG Li-juan, TANG Ri-yi, DING Yi, CAO Yan-feng. Research Progress in Action Mechanism of Feed Acidifier in Replacing Antibiotics and Its Application [J]. Animal Husbandry and Feed Science, 2021, 42(1): 51-55.
[6]	CHEN Yue-ji, YANG Na, SONG Zhi, LI Xian-yao. Application and Research Advances on Fulvic Acid in Livestock and Poultry Production [J]. Animal Husbandry and Feed Science, 2020, 41(4): 45-48.
[7]	LIU Li-xiao. Advances in Impacts of Medicated Feed Additives Residues on Ecological Environment [J]. Animal Husbandry and Feed Science, 2019, 40(9): 82-85.
[8]	ZHAO Meng, SONG Li-wen, HU Ming, GAO Min. Overview of Scientific Use of Feed Additives in Beef Cattle in the U.S.A. [J]. Animal Husbandry and Feed Science, 2019, 40(7): 43-47.
[9]	. Application and Research of Bacillus licheniformis in Feed Industry [J]. Animal Husbandry and Feed Science, 2017, 38(6): 26-26.
[10]	. Research Progress on Action Mechanism and Application of Diphtheria Toxin [J]. Animal Husbandry and Feed Science, 2017, 38(10): 33-33.
[11]	. Effect of Chinese Herb Feed Additives on Weight Gain and Blood Biochemical Index of Laying Chicks [J]. Animal Husbandry and Feed Science, 2015, 36(8): 64-64.
[12]	. The Application of Prebiotics of Inulin in Animal Production [J]. Animal Husbandry and Feed Science, 2015, 36(2): 41-41.
[13]	. Application of Microecological Agents in the Zoo [J]. Animal Husbandry and Feed Science, 2014, 35(10): 22-22.
[14]	. Optimization of Extraction Process of Baphicanthus Compound Feed Additives by Comprehensive Scoring Method [J]. Animal Husbandry and Feed Science, 2012, 33(3): 13-13.
[15]	. Effects of Chinese Herbal Feed Additives on Blood Indexes of Broilers [J]. Animal Husbandry and Feed Science, 2010, 31(3): 40-40.