千金藤碱功能及其制剂的研究进展

doi:10.12160/j.issn.1672-5190.2026.02.013

摘要/Abstract

摘要： 千金藤碱是从防己科（Menispermaceae）千金藤属（Stephania）千金藤和地不容等植物根茎中分离得到的一种生物碱,该化合物具有广谱的药理活性,在人医及兽医领域均具备极大的应用开发潜力。千金藤碱凭借抗炎、抗病毒、抗寄生虫及免疫调节等核心药理功效,可有效应对当前畜牧兽医行业面临的病毒性疫病频发、寄生虫耐药性凸显及畜禽机体免疫力低下等行业难题,是极具开发价值的备选药物。但千金藤碱自身水溶性差且口服吸收效率低,存在明显的体内生物利用度缺陷,严重制约了其临床转化与规模化应用进程。为攻克上述制剂短板,混悬液、微丸、微乳和纳米乳等多种新型药物递送系统被逐步应用于千金藤碱的制剂优化研发中。系统阐述千金藤碱的核心药理活性及作用机制,梳理其在相关领域的研究价值与应用前景,同时总结归纳其制剂优化的技术策略,旨在为千金藤碱在动物疫病防控和畜禽健康养殖等兽医领域的科研推进与临床应用提供科学参考与思路借鉴。

关键词: 千金藤碱, 药理功能, 制剂开发

Abstract: Cepharanthine is an alkaloid isolated from the rhizomes of plants such as Stephania japonica and Stephania epigaea in the genus Stephania of the family Menispermaceae. This compound has a broad spectrum of pharmacological activities and shows great potential for application and development in the field of human medicine and veterinary medicine. With the core pharmacological effects of anti-inflammation, anti-virus, anti-parasite and immune regulation, cepharanthine can effectively address the current problems of frequent viral diseases, prominent parasite resistance and low immunity of livestock and poultry in the animal husbandry and veterinary industry. It is an alternative drug with great development value. However, cepharanthine exhibits poor water solubility and low oral absorption efficiency, and has obvious low in vivo bioavailability, which seriously restricts its clinical translation and large-scale application. In order to overcome the shortcomings of the above formulations, a variety of new drug delivery systems such as suspensions, pellets, microemulsions and nanoemulsions have been gradually applied to the optimization and development of cepharanthine formulations. This paper systematically discusses the core pharmacological activities and mechanisms of action of cepharanthine, sorts out its research value and application prospect in related fields, and summarizes the technical strategies of its formulation optimization, aiming to provide scientific reference and theoretical insights for the scientific research promotion and clinical application of cepharanthine in veterinary fields such as animal disease prevention and control and livestock and poultry health breeding.

Key words: cepharanthine, pharmacological functions, formulation development

中图分类号:

S853.74

翁茂洋, 张雨霏, 杜依童, 高梦雅, 刘涵月, 杨淑琪, 张晨曦, 姜瑶. 千金藤碱功能及其制剂的研究进展[J]. 畜牧与饲料科学, 2026, 47(2): 101-106.

WENG Maoyang, ZHANG Yufei, DU Yitong, GAO Mengya, LIU Hanyue, YANG Shuqi, ZHANG Chenxi, JIANG Yao. Research Progress on Cepharanthine Functions and Its Formulations[J]. Animal Husbandry and Feed Science, 2026, 47(2): 101-106.

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