Abstract: Porcine colibacillosis is a kind of common disease for piglets from birth to weaning period and it is one of the major causes that led to the death of piglets. The research advances on the control of porcine colibacillosis in recent years were summarized. Taking the diagnosis and treatment of clinical cases as an example, the effective measures for the diagnosis and treatment of porcine colibacillosis were introduced, so as to provide references for the effective clinical treatment of porcine colibacillosis.