Abstract: Nramp 1 gene is one of candidate genes on disease resistance in breeding of livestock and poultry. Nramp 1 protein can resist a variety of intracellular bacteria, so the disease resistance of animal could be improved. The main characters and mechanism of Nramp 1 gene and the relationship between Nramp 1 gene and disease resistance characters were briefly reviewed, furthermore the application prospect of Nramp 1 gene was put forward.