灌喂石榴汁对大鼠体重及粪便和盲肠中鞣花酸、尿石素A含量的影响

doi:10.12160/j.issn.1672-5190.2019.07.003

Abstract

Abstract: ［Objective］ To determine whether feeding pomegranate juice would have effect on body weight and content of ellagic acid and urolithin A in feces and cecum contents in SD rats, and to provide data support for the in-depth study on biological effects of ellagic acid and urolithin A. ［Method］ A total of 24 male SD rats with an average body weight of （169.08±7.88） g were randomly divided into 3 groups （control group, test groupⅠand test groupⅡ） with 8 rats in each group. All of the excremental rats fed the same basal diet. The rats in test groupⅠand Ⅱ were fed with 1.5 mL and 3.0 mL of pomegranate juice per day, respectively. The rats were weighted and their feces and cecum contents were sampled. ［Result］ The daily weight gain of the rats in test group Ⅱ was increased by 36.32% （P<0.05） compared to the control group. Feeding pomegranate juice significantly （P<0.05） increased the content of ellagic acid and urolithin A in feces of rats, and extremely significantly （P<0.01） increased the content of ellagic acid and urolithin A in cecum contents of rats. ［Conclusion］ Feeding pomegranate juice for rats has significant or extremely significant effects on increasing the body weight and content of ellagic acid and urolithin A in feces and cecum contents, and the best effect was observed in the feeding volume of 3 mL per day per rat.

Key words: pomegranate juice weight urolithin A ellagic acid rats

CLC Number:

R285.5

CHEN Hui，LI Jia-hao，LI Chao，Subinuer•Aini，ZHAO Mei-yu，Yilimire•Paizireheman，Aikeliya•Tuheti，FANG Mei-yan. Effects of Pomegranate Juice on Body Weight and Content of Ellagic Acid and Urolithin A in Feces and Cecum Contents in Rats[J]. Animal Husbandry and Feed Science, 2019, 40(7): 11-14.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: https://journal30.magtechjournal.com/xmysl/EN/10.12160/j.issn.1672-5190.2019.07.003

https://journal30.magtechjournal.com/xmysl/EN/Y2019/V40/I7/11

References 18

[1]	GIL M I,TOMÁS-BARBERÁN F A,HESS-PIERCE B,et al. Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing[J].J Agric Food Chem,2000,48(10):4581-4589.
[2]	HEBER D,SCHULMAN R N,SEERAM N P.Pomegranates,Ancient Roots to Modern Medicine[M]. Boca Raton:CRC Press,2006.
[3]	张聪,盛磊,杨恬,等.鞣花酸对AKT基因转染诱导小鼠脂肪性肝病中炎症及氧化应激的影响[J].中国中药杂志,2019,44(9):1869-1875.
[4]	CERDÁ B, LLORACH R, CERÓN J J, et al. Evaluation of the bioavailability and metabolism in the rat of punicalagin, an antioxidant polyphenol from pomegranate juice[J].Eur J Nutr,2003,42(1):18-28.
[5]	CERDÁ B,TOMÁS-BARBERÁN F A,ESPÍN J C. Metabolism of antioxidant and chemopreventive ellagitannins from strawberries, raspberries, walnuts, and oak-aged wine in humans: identification of biomarkers and individual variability[J].J Agric Food Chem,2005,53(2):227-235.
[6]	SEERAM N P,HENNING S M,ZHANG Y,et al.Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 hours[J].J Nutr,2006,136(10):2481-2485.
[7]	MERTENS-TALCOTT S U,JILMA-STOHLAWETZ P,RIOS J,et al. Absorption, metabolism, and antioxidant effects of pomegranate (Punica granatum L.) polyphenols after ingestion of a standardized extract in healthy human volunteers[J].J Agric Food Chem, 2006,54(23):8956-8961.
[8]	张建伟. 板栗壳斗鞣花单宁及其代谢产物鞣花酸和尿石素A的生物活性研究[D].北京:北京林业大学,2015.
[9]	冯立娟,陶吉寒,尹燕雷,等.石榴功能物质鞣花酸研究进展[J].食品科学,2014,35(23):325-330.
[10]	CERDÁ B,TOMÁS-BARBERÁN F A,ESPÍN J C. Metabolism of antioxidant and chemopreventive ellagitannins from strawberries, raspberries, walnuts, and oak-aged wine in humans: identification of biomarkers and individual variability[J].J Agric Food Chem, 2005, 53(2): 227-235.
[11]	韩淇安,刘红燕,闫春红,等.尿石素A对巨噬细胞极化及巨噬-泡沫细胞形成的作用[J].食品科学,2017,38(13):182-189.
[12]	LARROSA M,GONZÁLEZ-SARRÍAS A,GARCÍA-CONESA M T,et al. Urolithins, ellagic acid-derived metabolites produced by human colonic microflora, exhibit estrogenic and antiestrogenic activities[J].J Agric Food Chem,2006,54(5):1611-1620.
[13]	LARROSA M, GONZÁLEZ-SARRÍAS A, YÁÑEZ-GASCÓN M J,et al. Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-a in a colitis rat model and the effect of colon inflammation on phenolic metabolism[J].J Nutr Biochem,2009,21(8):717-725.
[14]	李乐愚,林慧,梅全喜,等.复方番石榴制剂对2型糖尿病模型大鼠空腹血糖及胰岛素敏感性的影响[J].时珍国医国药,2015,26(11):2644-2646.
[15]	BIALONSKA D, KASIMSETTY S G, KHAN S I,et al.Urolithins, intestinal microbial metabolites of pomegranate ellagitannins, exhibit potent antioxidant activity in a cell-based assay[J].J Agric Food Chem,2009,57(21):10181-10186.
[16]	周本宏,凃杰,金龙,等.石榴皮鞣质在大鼠体内的代谢产物分析[J].中国药学杂志,2014,49(10):821-824.
[17]	全燚,何君.安石榴苷在大鼠体内代谢转化的初探[C]//中国毒理学会中药与天然药物毒理专业委员会第一次(2016年)学术交流大会论文集.天津:中国毒理学会中药与天然药物毒理专业委员会,2016.
[18]	孙长豹,刘志静,刘飞,等.食物成分对肠道菌群结构的影响[J].食品研究与开发,2018,39(9):178-182.

Effects of Pomegranate Juice on Body Weight and Content of Ellagic Acid and Urolithin A in Feces and Cecum Contents in Rats

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References 18

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	BAO Xu, BIAN Kangkun, XIAO Haijun, WANG Li, BAO Yulong. Honghua Qinggan 13 Flavor Pill Alleviates Liver Injury in Mice through Inhibiting Inflammatory Cell Infiltration [J]. Animal Husbandry and Feed Science, 2024, 45(1): 1-10.
[2]	XIAO Haijun, BIAN Kangkun, BAO Xu, BAO Yulong, WANG Li. Improving Liver Function by Activating HNF4α Is a Mechanism Underlying the Hepatoprotective Effects of Honghua Qinggan 13 Flavor Pill,a Traditional Mongolian Medicine [J]. Animal Husbandry and Feed Science, 2024, 45(1): 11-19.
[3]	WEI Yuanyuan, Hongmei, WANG Haisheng. Transcriptome Sequencing Analysis Reveals the Possible Therapeutic Mechanisms of a Traditional Mongolian Medicine Honghua Qinggan 13 Flavor Pills in CCl₄ Induced Intestinal Injury in Mice [J]. Animal Husbandry and Feed Science, 2023, 44(6): 13-21.
[4]	ZHANG Yan-da, PAN Hui-qing, YUAN Lv-jiang, LIU Han-ru, ZHAO Qi. Systematic Evaluation of Safety and Antioxidant Activity of Pseudostellaria heterophylla Based on in Vitro Cell Model [J]. Animal Husbandry and Feed Science, 2020, 41(3): 80-85.
[5]	JIN Xue-qin,LI Wei-hua,LI Zhi-mei,HE Sheng-cun,PAN Lin(Experimental Animal Center,Ningxia Medical University,Yinchuan 750004,China,College of Pharmacy,Ningxia Medical University,Yinchuan 750004,China,Chinese Medical College,Ningxia Medical University,Yinchuan 750004,China,Department of Clinical Laboratory,Ningxia Medical University Hospital,Yinchuan 750004,China). Regulative Effect of Oxymatrine on Liver TGF-β1 of Rats with Liver Fibrosis [J]. Animal Husbandry and Feed Science, 2018, 39(12): 13-16.
[6]	. [J]. Animal Husbandry and Feed Science, 2017, 38(11): 15-15.
[7]	. Inhibitory Effect and Mechanism of Plant-derived Saponins on Animal Inflammation and Its Feasibility in Production of Livestock and Poultry [J]. Animal Husbandry and Feed Science, 2017, 38(9): 51-51.
[8]	. Research Progress on Antibacterial Activity of Baicalin [J]. Animal Husbandry and Feed Science, 2017, 38(7): 61-61.
[9]	. Research Progress on Cerebral Protection of Astragaloside Ⅳ [J]. Animal Husbandry and Feed Science, 2017, 38(6): 62-62.
[10]	. Sedative and Hypnotic Effect of Pachyman on Mice [J]. Animal Husbandry and Feed Science, 2017, 38(4): 73-73.
[11]	. Research Progress on Ligusticum chuanxiong Hort. [J]. Animal Husbandry and Feed Science, 2017, 38(4): 71-71.
[12]	. Preventive Effect of Seaweed Functional Food against Hyperlipidemia of Mice [J]. Animal Husbandry and Feed Science, 2017, 38(3): 42-42.
[13]	. Effect of Cistanche tubulosa Ethanol Extract on Blood Biochemical Parameters and Cardiovascular Function in Rats [J]. Animal Husbandry and Feed Science, 2016, 37(6): 16-16.
[14]	. [J]. Animal Husbandry and Feed Science, 2015, 36(11): 10-10.
[15]	. [J]. Animal Husbandry and Feed Science, 2015, 36(11): 1-1.