沉默信息调节因子2相关酶3调控机制及其在疾病中的作用

doi:10.12160/j.issn.1672-5190.2023.01.005

Abstract

Abstract:

Silent information regulator 2-related enzyme 3 （SIRT3）, a member of nicotinamide adenine dinucleotide （NAD⁺）-dependent histone deacetylase family, gets involved and plays important roles in energy metabolism, oxidative stress and apoptosis. Its regulatory roles are closely associated with the occurrence of several diseases. This paper reviews the regulatory mechanisms of downstream transcription factors of SIRT3 such as AMP-activated protein kinase （AMPK）, mitochondrial permeability transition pore （mPTP） and nuclear factor-κB （NF-κB）, as well as the roles of SIRT3 in cardiovascular diseases, tumors and diabetes mellitus, in hoping to provide references for the prevention and treatment of related diseases.

Key words: silent information regulator 2-related enzyme 3, Sirtuin, mitochondria, reactive oxygen species, diseases

CLC Number:

SHA Ping, JI Si-tong, CAO Pei-pei, LI Meng-ji, MA Yan-fen. Regulatory Mechanisms of Silent Information Regulator 2-related Enzyme 3 and Its Roles in Diseases[J]. Animal Husbandry and Feed Science, 2023, 44(1): 32-37.

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Regulatory Mechanisms of Silent Information Regulator 2-related Enzyme 3 and Its Roles in Diseases

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