TCDCA对IL-1β刺激下AA大鼠成纤维样滑膜细胞中PGE2分泌的影响

doi:10.12160/j.issn.1672-5190.2021.05.001

Abstract

Abstract: [Objective] To further assess the potential anti-inflammatory and immunomodulatory roles of taurochenodeoxycholic acid （TCDCA）. [Method] The fibroblast-like synoviocytes （FLS） of adjuvant arthritis （AA） rats were used as experimental research objects. The contents of prostaglandin E₂（PGE₂） in supernatant of FLS co-incubated with TCDCA and IL-1β were determined by ELISA to evaluate the effect of TCDCA on PGE₂ excretion with stimulation of IL-1β. [Result] TCDCA significantly （P<0.05） reduced the PGE₂ excretion level with stimulation of IL-1β in FLS of AA rats. [Conclusion] TCDCA has inhibitory effect on PGE₂ excretion with stimulation of IL-1β in FLS of AA rats, which provides reference for application of TCDCA in veterinary clinic practice.

Key words: taurochenodeoxycholic acid, fibroblast-like synoviocytes, prostaglandin E₂

CLC Number:

S853.74

JIANG Xue-ying, QIAN Ying-hong, ZHAO Jun-li, ZHANG Kai, DUAN Yan, LI Pei-feng, HE Xiu-ling, MAO Wei, CAO Jin-shan, GUO Wen-rui. Effect of Taurochenodeoxycholic Acid on PGE₂ Excretion of Fibroblast-like Synoviocytes in Adjuvant Arthritis Rats with Stimulation of IL-1β[J]. Animal Husbandry and Feed Science, 2021, 42(5): 1-5.

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Effect of Taurochenodeoxycholic Acid on PGE₂ Excretion of Fibroblast-like Synoviocytes in Adjuvant Arthritis Rats with Stimulation of IL-1β

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Effect of Taurochenodeoxycholic Acid on PGE2 Excretion of Fibroblast-like Synoviocytes in Adjuvant Arthritis Rats with Stimulation of IL-1β

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Effect of Taurochenodeoxycholic Acid on PGE₂ Excretion of Fibroblast-like Synoviocytes in Adjuvant Arthritis Rats with Stimulation of IL-1β