Abstract: The aim was to study the influence of natural wild Ciwujia from Changbai Mountain on the blood glucose in diabetic animal model in the trial. 40 Kunming mice were selected and fasted for 12 h. The experimental model of mice in diabetes was established by administrating abdominal cavity of alloxan and selective destructing of islet β cells. The trial animals were divided into four groups,namely high-dose（HD）,medium-dose（MD）,Low-dose （LD） and alloxan model（AM）,10 normal Kunming mice with proximate body weight were used as the control group. HD,MD and LD respectively was given by intragastric administration at dosage of 5.00,1.25,0.25 g/kg of Ciwujia decoction,AM and control group was treated by saline with the same volume and way. After continuously intragastric administration for 15 days,the fasting blood glucose was determined to observe its changes regularity of the mice. Results the blood glucose contents in HD and MD respectively were （13.51 ± 1.42） mmol/L,（15.39 ± 0.79） mmol/L,they in blood glucose were significantly lower that of the control （19.62±1.28） mmol/L （P〈0.01）. Meanwhile,the blood glucose in LD was （17.39±0.64） mmol/L,compared with the control,there was markedly different （P 〈0.05）. In conclusion,Changbai Mountain wild Ciwujia have the hypoglycemic effect to the experimental mice.