Abstract: Bioengineering is a major with high practical requirements. Experimental design is one of the compulsory courses for this major, which is very important to cultivate undergraduates′ engineering thinking ability and innovation ability. At present, the Experimental Design of bioengineering major in agricultural colleges and universities is mostly set up independently, and the theoretical knowledges of experimental design are irrelative to the specific experimental courses. It is difficult for undergraduates to apply the principles and methods obtained from this course to the specific experimental process, resulting in the disconnect between theory and experiment. In this study,the experimental design method is integrated into the Bioreaction Engineering Experiment, and the teaching practice is carried out with the example of ′the experiment of producing surfactant by fermentation using Bacillus subtilis′, in hoping to make the undergraduates master the optimizing design method and to improve their engineering design abilities and practical innovation abilities.

Key words: Experimental Design, Bioreaction Engineering Experiment, process optimization, computer software, teaching reform