Abstract: Based on the scientific research results of teachers, students＇ information and scientific literature, the teaching cases that was not only related to the major, but it could also arouse students＇ passion and trigger students＇ creative thinking were wrote. And the teaching effects of applying the written cases were analyzed, so as to play the promotive effects of case teaching in the teaching and learning of biological statistics and experimental design course. The application experiences of case teaching in the biological statistics and experimental design course were summarized.