Abstract: Translational medicine is a newly proposed medical thought which serves as a bridge between basic medical research and clinical medicine.The significant roles of translational medicine in higher medical education have been gradually known by teachers.Medical Biochemistry and Molecular Biology is one of the frontier disciplines in life science and is an important elementary course for medical undergraduates.To solve the existing problems in teaching of this course,some proposals are put forward based on the translational medicine thinking,so as to simulate the study enthusiasm and initiative of the undergraduates and to improve the teaching quality of Medical Biochemistry and Molecular Biology.