Abstract: Pharmacology is a discipline to study the interactions between drugs and pathogen, animals and their mechanism, which is a bridge between basic medicine and clinical medicine. Application-oriented university is a kind of university with application type as teaching orientation. The application-oriented undergraduate education could play a positively-promoting role for meeting the China＇s economic and social development and the high-level and application-oriented talents, and promoting the popularization process of higher education in China. Anhui Science and Technology University is the first application-oriented college in Anhui Province. According to the training project of application-oriented talents and the training targets of talents, the curriculum of Pharmacology was reconstructed so as to adapt the new training project of talents.