Abstract: Veterinary Epidemiology is a discipline mainly focusing on the distribution of diseases frequency in flocks and its decisive factors. In order to improve the teaching quality and to actively cooperate with the teaching mode transformation in which undergraduates serve as the main body, a series of new teaching methods, such as PBL, TBL and case teaching methods were used in teaching of Veterinary Epidemiology. The application of these teaching methods greatly stimulates the undergraduates′ learning enthusiasm and helps undergraduates establish the concept of innovation and team. All of these newly applied teaching methods have obtained satisfied teaching effect.