Abstract: In order to improve the teaching effect of Animal Husbandry Microbiology practice, task-driven method was applied in practical teaching. A total of 62 students from 2 classes were randomly divided into four test groups. Task-driven method and conventional method were applied respectively. Students were scored based on the results of task completion and questionnaire.The results showed that the students in group 1 and group 3 who were taught with task-driven method had a much better grasp of practical contents compared to the students in group 2 and group 4 who were taught with conventional method, and the former had higher participation and enthusiasm for experiment content compared to the latter. In written examination of experimental course,there were 12 and 15 students in task-driven method taught groups who were able to completely master the knowledge they had learned respectively, accounting for 85.0% and 93.7% of the total number of students respectively; there were 5 and 6 students in conventional method taught groups who were able to completely master the knowledge they had learned respectively, accounting for 33.3% and 37.5% of the total number of students respectively, but they had lower participation and enthusiasm compared to the students in task-driven method taught groups. The results proved that the introduction of task-driven method in the Animal Husbandry Microbiology practice can obviously improve the teaching effect.