Abstract: Biostatistics is a professional and basic course with strong theoretical and practical property. Therefore, in order to overcome the current situation of ＂learning difficulty for students, teaching difficulty for teachers＂ in the teaching process, a mobile teaching APP of Moso Teach combined with the teaching mode of flipped classroom were designed and implemented in the course of Biostatistics. The results showed that the teaching model inspired the enthusiasm of students to learn, enhanced the teaching effect, and promoted the students＇ mastery and flexible use of statistical knowledge.