Abstract: Based on the analysis of the present situation of experimental teaching of Animal Microbiology and Immunology in College of Veterinary Medicine of Henan University of Animal Husbandry and Economy, the specific methods and measures of teaching reform are discussed from the aspects of improving the experimental teaching environment, expanding the content of experimental teaching, introducing new teaching modes such as Moso Teach, and refining the experimental evaluation program to improve the quality of experimental teaching and students＇ practical ability, in hoping to better cultivate excellent talents in specialties of animal husbandry and veterinary medicine.