Abstract: Animal Physiology is one of the core courses in animal medicine and animal science specialties, and is also a curriculum that integrates theory with practice. The application -oriented undergraduate teaching focuses on the cultivation of undergraduates′ innovative and practical abilities. Therefore, combining with the talent cultivation objectives of application - oriented undergraduate and the characteristics of the curriculum itself, on the basis of teaching practice, the reform of paradigm teaching was explored from the aspects of comparison between the traditional and new paradigms, learning models and auxiliary courses, in hoping to lay a theoretical foundation for the training of qualified application-oriented talents.