Abstract: The deficiency in undergraduates′ practical ability and job adaptive ability is the commonly observed problem in higher education. To enhance the practical education in universities and colleges, especially the inside-school practice course and outside-school practice education, is an effective way to resolute the contradiction between higher education and enterprise demand. Micro-class refers to the structurized digital resource which displays the fragmented learning content, process and expanded material by using information technology in accordance with the cognitive law. Micro-class is characterized by its concise and contextualized content and is especially suitable for outside-school practice course. In this paper, taking the practice course of Pharmaceutical Preparation as an example, we investigate the ways to construct micro-class in practical education of universities and colleges and the roles of micro-class playing in training of applied talents.