Abstract: SPOC is a newly emerged educational model in post-MOOC period which renders online open class resources for the small-scale users such as a single university and even a single class.It is favorable for the fusion of MOOC and classroom teaching.Under the background of rapid development of educational information,how to organically integrate the blended teaching model of SPOC with the specialized courses teaching has become a new exploring direction for teachers.Here,we firstly analyzed the suitability of the application of SPOC model in Genetic Engineering of biological major;furthermore,we built the SPOC-based blended teaching model in Genetic Engineering to promote the teaching reform process of this course in the new situation.